Rabbit anti-Human CYP2C19 Polyclonal Antibody | anti-CYP2C19 antibody

CYP2C19 Polyclonal Antibody

Cat. Num. AAA2559769

• Gene Names: CYP2C19; CPCJ; CYP2C; P450C2C; CYPIIC17; CYPIIC19; P450IIC19
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Antigen Affinity Purification
• Synonyms: CYP2C19; Polyclonal Antibody; CYP2C19 Polyclonal Antibody; (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CP2CJ; CPCJ; CYP2C; CYPIIC17; CYPIIC19; Cytochrome P-450 II C; Cytochrome P450 2C19; Cytochrome P450; Subfamily IIC (mephenytoin 4-hydroxylase); Polypeptide 19; Cytochrome P450-11A; Cytochrome P450-254C; Flavoprotein-linked monooxygenase; Mephenytoin 4 hydroxylase; Mephenytoin 4-hydroxylase; Microsomal monooxygenase; P450-11A; P45011A; P450C2C; S-mephenytoin 4-hydroxylase; Xenobiotic monooxygenase; anti-CYP2C19 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purification
• Form/Format: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Concentration: 0.7mg/mL (varies by lot)
• Sequence Length: 490

• Applicable Applications for anti-CYP2C19 antibody: Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: IHC: 1:25-1:100; ELISA: 1:5000-1:10000
• Immunogen: Synthetic peptide of human CYP2C19
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using CYP2C19 Polyclonal Antibody at dilution of 1:25(×200))

Related Product Information for anti-CYP2C19 antibody

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.CYP2C19 (Cytochrome P450 Family 2 Subfamily C Member 19) is a Protein Coding gene. Diseases associated with CYP2C19 include Mephenytoin Poor Metabolizer and Cyp2c19-Related Altered Drug Metabolism. Among its related pathways are Cytochrome P450 - arranged by substrate type and Paroxetine Pathway, Pharmacokinetics. GO annotations related to this gene include enzyme binding and iron ion binding. An important paralog of this gene is CYP2C9.

Product Categories/Family for anti-CYP2C19 antibody

Cancer; Cardiovascular; Metabolism; Signal transduction

NCBI and Uniprot Product Information

• NCBI GI #: 4503219
• NCBI GeneID: 1557
• NCBI Accession #: NP_000760.1
• NCBI GenBank Nucleotide #: NP_000760.1
• UniProt Accession #: P33261
• NCBI Official Full Name: cytochrome P450 2C19
• NCBI Official Synonym Full Names: cytochrome P450 family 2 subfamily C member 19
• NCBI Official Symbol: CYP2C19
• NCBI Official Synonym Symbols: CPCJ; CYP2C; P450C2C; CYPIIC17; CYPIIC19; P450IIC19
• NCBI Protein Information: cytochrome P450 2C19
• UniProt Protein Name: Cytochrome P450 2C19
• Protein Family: Cytochrome
• UniProt Gene Name: CYP2C19
• UniProt Entry Name: CP2CJ_HUMAN

NCBI Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]