Western Blot (WB)
(Western blot analysis of CYP2C18 Antibody (C-term) in HL-60 cell line lysates (35ug/lane). CYP2C18 (arrow) was detected using the purified Pab.)
Rabbit anti-Human CYP2C18 Polyclonal Antibody | anti-CYP2C18 antibody
CYP2C18 Antibody (C-term)
Western Blot (WB)
(Western blot analysis of CYP2C18 Antibody (C-term) in HL-60 cell line lysates (35ug/lane). CYP2C18 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of CYP2C18 Antibody (C-term) in HL-60 cell line lysates (35ug/lane). CYP2C18 (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with CYP2C18 Antibody (C-term),which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with CYP2C18 Antibody (C-term),which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Nelson,D.R., et.al., Pharmacogenetics 14 (1), 1-18 (2004)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
CYP2C18: a member of the cytochrome P450 superfamily of enzymes. Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. Participates in the oxidation of a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.
Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase; EC 1.14.14.1; Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid; Cofactor and Vitamin Metabolism - retinol
Chromosomal Location of Human Ortholog: 10q24
Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle; cytoplasm
Molecular Function: iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; heme binding; arachidonic acid epoxygenase activity; steroid hydroxylase activity; oxygen binding; monooxygenase activity
Biological Process: xenobiotic metabolic process; exogenous drug catabolic process; epoxygenase P450 pathway
Research Articles on CYP2C18
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Product Notes
The CYP2C18 cyp2c18 (Catalog #AAA9203200) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 448-478. The CYP2C18 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CYP2C18 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the CYP2C18 cyp2c18 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CYP2C18, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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