Rabbit anti-Human, Mouse CYP26C1 Polyclonal Antibody | anti-CYP26C1 antibody

CYP26C1, CT (Cytochrome P450 26C1) (MaxLight 550)

Cat. Num. AAA6471346

• Gene Names: CYP26C1; FFDD4
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified by Ammonium Sulfate Precipitation.
• Synonyms: CYP26C1; Polyclonal Antibody; CT (Cytochrome P450 26C1) (MaxLight 550); anti-CYP26C1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CYP26C1. Species Crossreactivity: mouse.
• Purity/Purification: Purified by Ammonium Sulfate Precipitation.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

• Applicable Applications for anti-CYP26C1 antibody: Immunohistochemistry (IHC), FLISA, Western Blot (WB)
• Application Notes: IHC: 1:50-1:100; FLISA: 1:1,000; WB: 1:50-1:100; Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide selected from the C-terminal region of human CYP26C1 (KLH).
• Conjugate: MaxLight550
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western blot analysis of anti-CYP26C1 Antibody (C-term) in mouse brain tissue lysates (35ug/lane). CYP26C1(arrow) was detected using the purified Pab.)

Immunohistochemistry (IHC)

(Formalin-fixed and paraffin-embedded human brain tissue reacted with CYP26C1 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)

Product Categories/Family for anti-CYP26C1 antibody

Antibodies; Enzymes; Cytochrome

References

1. Rat, E., Birth Defects Res. Part A Clin. Mol. Teratol. 76(6), 491-498 (2006). 2. Taimi, M., J. Biol. Chem. 279(1), 77-85 (2004). 3. Nelson, D.R., Pharmacogenetics 14(1), 1-18 (2004).

NCBI and Uniprot Product Information

• NCBI GI #: 62952502
• NCBI GeneID: 340665
• NCBI Accession #: NP_899230
• NCBI GenBank Nucleotide #: NM_183374.2
• UniProt Accession #: Q6V0L0; Q5VXH6
• Molecular Weight: 57,111 Da
• NCBI Official Full Name: cytochrome P450 26C1
• NCBI Official Synonym Full Names: cytochrome P450 family 26 subfamily C member 1
• NCBI Official Symbol: CYP26C1
• NCBI Official Synonym Symbols: FFDD4
• NCBI Protein Information: cytochrome P450 26C1
• UniProt Protein Name: Cytochrome P450 26C1
• Protein Family: Cytochrome
• UniProt Gene Name: CYP26C1
• UniProt Entry Name: CP26C_HUMAN

NCBI Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome 10q23.33. [provided by RefSeq, Jul 2008]

Uniprot Description

CYP26C1: Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate). Belongs to the cytochrome P450 family.

Protein type: Membrane protein, integral; Cell development/differentiation; EC 1.14.-.-; Oxidoreductase; Cofactor and Vitamin Metabolism - retinol

Chromosomal Location of Human Ortholog: 10q23.33

Cellular Component: endoplasmic reticulum membrane; integral to membrane

Molecular Function: retinoic acid binding; iron ion binding; retinoic acid 4-hydroxylase activity; heme binding

Biological Process: anterior/posterior pattern formation; negative regulation of retinoic acid receptor signaling pathway; central nervous system development; vitamin metabolic process; organelle fusion; neural crest cell development; xenobiotic metabolic process

Disease: Focal Facial Dermal Dysplasia 4