Western Blot (WB)
(Fig. Western Blot analysis of various cells using Cyclin L1 Polyclonal Antibody diluted at 1:1000.)
Rabbit Cyclin L1 Polyclonal Antibody | anti-CCNL1 antibody
Cyclin L1 Polyclonal Antibody
Gene Names
CCNL1; ANIA6A; BM-001; PRO1073; ania-6a
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry, ELISA
Purity
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
Cyclin L1; Polyclonal Antibody; Cyclin L1 Polyclonal Antibody; Rabbit Anti-Cyclin L1 Polyclonal Antibody; BM-001; Cyclin-L1; Cyclin-L; anti-CCNL1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Cyclin L1 Polyclonal Antibody detects endogenous levels of Cyclin L1 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid; PBS Containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
526
Applicable Applications for anti-CCNL1 antibody
Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA)
Application Notes
WB: 1:500-1:2000
IHC-P: 1:100-1:300
ELISA: 1:10000
IHC-P: 1:100-1:300
ELISA: 1:10000
Immunogen
Synthesized peptide derived from the C-terminal region of human Cyclin L1 at AA range: 430-510
Preparation and Storage
Stable for one year at -20 degree C from date of shipment.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Western Blot (WB)
(Fig. Western Blot analysis of various cells using Cyclin L1 Polyclonal Antibody diluted at 1:1000.)
Western Blot (WB)
(Fig. Western Blot analysis of various cells using Cyclin L1 Polyclonal Antibody diluted at 1:1000.)
Related Product Information for anti-CCNL1 antibody
Cell proliferation is controlled at specific stages of the cell cycle by distinct protein kinase complexes. These complexes consist of a catalytic subunit associating with a specific regulatory subunit to form the active kinase. The cyclins, which include cyclin A, B, C, D, E, F, G, H, I, K, L, T and their related proteins, including Dbf4, comprise the regulatory subunits of these kinase complexes. The controlled activation of the kinase complexes at various intervals of the cell cycle is regulated by the availability of the cyclins to the catalytic subunit. Unlike the catalytic subunit, which is expressed continually, the expression and stability of the regulatory subunit fluctuates depending on the stage of the cell cycle and, thereby, regulates the kinase activity. Cyclin L1 is a ubiquitously expressed nuclear protein that can be detected in higher levels in thymus. In neck and head squamous cell carcinomas, cyclin L1 can be overexpressed and is therefore often considered a proto-oncogene. It interacts with POLR2A, CDC2L and SFRS2. Cyclin L1 plays a role in the mRNA splicing process regulation.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
cyclin-L1 isoform 1
NCBI Official Synonym Full Names
cyclin L1
NCBI Official Symbol
CCNL1
NCBI Official Synonym Symbols
ANIA6A; BM-001; PRO1073; ania-6a
NCBI Protein Information
cyclin-L1
UniProt Protein Name
Cyclin-L1
Protein Family
UniProt Gene Name
CCNL1
UniProt Synonym Gene Names
Cyclin-L
UniProt Entry Name
CCNL1_HUMAN
Uniprot Description
CCNL1: cyclin L1, a member of the cyclin family. Associates with the PITSLRE kinase and is involved in pre-mRNA processing.
Protein type: Cell cycle regulation; Oncoprotein
Chromosomal Location of Human Ortholog: 3q25.31
Cellular Component: nuclear speck; nucleus
Molecular Function: protein kinase binding
Biological Process: RNA processing; transcription, DNA-dependent; regulation of transcription, DNA-dependent; regulation of cyclin-dependent protein kinase activity
Research Articles on CCNL1
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Product Notes
The CCNL1 ccnl1 (Catalog #AAA9701803) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cyclin L1 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Cyclin L1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA). WB: 1:500-1:2000 IHC-P: 1:100-1:300 ELISA: 1:10000. Researchers should empirically determine the suitability of the CCNL1 ccnl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cyclin L1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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