Rabbit Cyclin Dependent Kinase Inhibitor 2C Polyclonal Antibody | anti-CDKN2C antibody
Cyclin Dependent Kinase Inhibitor 2C (CDKN2C, INK4C, p18, p18-INK4C) (Biotin)
Applications are based on unconjugated antibody.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
CDKN2C: Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB. Heterodimer of p18 with CDK6. Highest levels found in skeletal muscle. Also found in pancreas and heart. Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Protein type: Cell cycle regulation; Protein kinase, regulatory subunit; Inhibitor
Chromosomal Location of Human Ortholog: 1p32
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: cyclin-dependent protein kinase inhibitor activity; protein binding; protein kinase binding
Biological Process: negative regulation of cell proliferation; oligodendrocyte differentiation; negative regulation of phosphorylation; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; negative regulation of cell growth; cell cycle arrest; G1/S transition of mitotic cell cycle
Research Articles on CDKN2C
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Product Notes
The CDKN2C cdkn2c (Catalog #AAA6413342) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cyclin Dependent Kinase Inhibitor 2C (CDKN2C, INK4C, p18, p18-INK4C) (Biotin) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Cyclin Dependent Kinase Inhibitor 2C can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IHC: 1:50-1:200 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the CDKN2C cdkn2c for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cyclin Dependent Kinase Inhibitor 2C, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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