Rabbit anti-Human Cyclin Dependent Kinase 2 (CDK2) Polyclonal Antibody | anti-CDK2 antibody
FITC-linked Antibody to Cyclin Dependent Kinase 2 (CDK2)
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
NCBI and Uniprot Product Information
Uniprot Description
CDK2: a protein kinase of the CDK family. An important component of the cell cycle machinery. Activity of CDK2 is maximal during S phase and G2. Cdk2/cyclin E kinase activity is important for the G1 to S transition and phosphorylates the Rb protein. In S-phase, active cdk2/cyclin A complexes predominate and phosphorylate E2F, and the active cdk2 complex persists in the nucleus through G2. Part of the Rb pathway disregulated in most tumors. Target of several candidate cancer drugs. However, inhibition does not always prevent cancer cell growth, possibly due to CDK redundancy. Inhibitors: BMS-265246, BMS-265246-01, R-roscovitine (CYC200, CYC202), SU9516, R547, L868276
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.22; Protein kinase, CMGC; Cell cycle regulation; Kinase, protein; CMGC group; CDK family; CDK1 subfamily; CDK/CDK1 subfamily
Cellular Component: Y chromosome; Cajal body; chromosome, telomeric region; transcription factor complex; intracellular membrane-bound organelle; X chromosome; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; microtubule organizing center; condensed chromosome; cytosol; nucleus; endosome
Molecular Function: cyclin binding; cyclin-dependent protein kinase activity; metal ion binding; protein complex binding; histone kinase activity; kinase activity; ATP binding; protein kinase activity
Biological Process: lens development in camera-type eye; response to drug; mitosis; organ regeneration; response to cAMP; regulation of cell cycle; histone phosphorylation; positive regulation of transcription, DNA-dependent; response to toxin; DNA repair; protein amino acid phosphorylation; response to estradiol stimulus; peptidyl-serine phosphorylation; response to cadmium ion; response to ethanol; cellular response to insulin stimulus; meiotic cell cycle; cell division; Ras protein signal transduction; positive regulation of cell proliferation; response to electrical stimulus; potassium ion transport; positive regulation of DNA replication initiation; G1/S transition of mitotic cell cycle
Research Articles on CDK2
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Product Notes
The CDK2 cdk2 (Catalog #AAA2014835) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The FITC-linked Antibody to Cyclin Dependent Kinase 2 (CDK2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Cyclin Dependent Kinase 2 (CDK2) can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the CDK2 cdk2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cyclin Dependent Kinase 2 (CDK2), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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