Rabbit CX3CL1 Polyclonal Antibody | anti-CX3CL1 antibody

CX3CL1 Antibody FITC

Cat. Num. AAA5400377

• Gene Names: Cx3cl1; CX3C; Cxc3; Scyd1; ABCD-3; AB030188; AI848747; D8Bwg0439e
• Reactivity: Human, Monkey, Mouse, Rat
• Applications: ELISA, Immunoprecipitation, Western Blot
• Purity: Immobilized antigen affinity chromatography
• Synonyms: CX3CL1; Polyclonal Antibody; CX3CL1 Antibody FITC; FITC-Conjugated Fractalkine Antibody; A 152E5.2 antibody; AB030188 antibody; ABCD3 antibody; AI848747 antibody; C-X3-C motif chemokine 1 antibody; C3Xkine antibody; Chemokine C X3 C motif ligand 1 antibody; CX3C membrane anchored chemokine antibody; Cx3cl1 antibody; CXC3 antibody; CXC3C antibody; D8Bwg0439e antibody; FKN antibody; Fractalkine antibody; Neurotactin antibody; NTN antibody; NTT antibody; Processed fractalkine antibody; SCYD 1 antibody; Small inducible cytokine D1 antibody; X3CL1_HUMAN antibody; anti-CX3CL1 antibody

• Host: Rabbit
• Reactivity: Human, Monkey, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Immobilized antigen affinity chromatography
• Concentration: 0.5 ug/ul in antibody stabilization buffer (varies by lot)
• Sequence Length: 395

• Applicable Applications for anti-CX3CL1 antibody: ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: ELISA: 1:10,000; IP: 1:150; WB: 1:500
• Immunogen: Synthetic peptide taken within amino acid reigon 350-395 on mouse Fractalkine protein.
• Conjugation: FITC
• Molecular Function: CCR chemokine receptor binding; chemokine activity; CX3C chemokine receptor binding; integrin binding
• Subcellular Location: Cell Membrane; Single-pass type I membrane protein; Processed fractalkine: Secreted
• Preparation and Storage: Store at -20 degree C for long term storage.

Related Product Information for anti-CX3CL1 antibody

Overview: Acts as a ligand for both CX3CL1 and integrins. Binds to CX3CR1 and to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9177350, PubMed:10382755).

Structure: Signal, Transmembrane, Transmembrane helix

Expression: Highest levels in brain. Lower levels in kidney, heart and lung. Also found in skeletal muscle and testis.

NCBI and Uniprot Product Information

• NCBI GI #: 31982017
• NCBI GeneID: 20312
• NCBI Accession #: NP_033168.2
• NCBI GenBank Nucleotide #: NM_009142.3
• UniProt Accession #: O35188; O35933; Q91V44
• Molecular Weight: 42,099 Da
• NCBI Official Full Name: fractalkine
• NCBI Official Synonym Full Names: chemokine (C-X3-C motif) ligand 1
• NCBI Official Symbol: Cx3cl1
• NCBI Official Synonym Symbols: CX3C; Cxc3; Scyd1; ABCD-3; AB030188; AI848747; D8Bwg0439e
• NCBI Protein Information: fractalkine
• UniProt Protein Name: Fractalkine
• Protein Family: Fractalkine
• UniProt Gene Name: Cx3cl1
• UniProt Synonym Gene Names: Cx3c; Fkn; Scyd1

Uniprot Description

Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 and to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (). The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9177350, PubMed:10382755).