Western Blot (WB)
(CUGBP2 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CUGBP2 antibody detected the CUGBP2 protein (arrow).)
Rabbit anti-Human CUGBP2 Polyclonal Antibody | anti-CELF2 antibody
CUGBP2, CT (CELF2, BRUNOL3, CUGBP2, ETR3, NAPOR, CUGBP Elav-like family member 2, Bruno-like protein 3, CUG triplet repeat RNA-binding protein 2, CUG-BP- and ETR-3-like factor 2, ELAV-type RNA-binding protein 3, Neuroblastoma apoptosis-related RNA-binding
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(CUGBP2 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CUGBP2 antibody detected the CUGBP2 protein (arrow).)
Western Blot (WB)
(CUGBP2 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CUGBP2 antibody detected the CUGBP2 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury
By similarity. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression
By similarity. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs. Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds AU-rich sequences in the 3'-UTR of COX2 mRNA
By similarity. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing
By similarity. Binds to (CUG)n repeats
By similarity. Ref.11 Ref.12 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17
Subunit structure: Interacts with A1CF
By similarity.
Subcellular location: Nucleus. Cytoplasm. Note: Accumulates in the cytoplasm after ionizing radiation
By similarity. Colocalizes with APOBEC1 and A1CF. RNA-binding activity is detected in both nuclear and cytoplasmic compartments. Ref.10 Ref.11 Ref.15
Tissue specificity: Expressed in frontal cortex. Isoform 1 is expressed in brain and lung. Isoform 2 is expressed in heart, brain, placenta, lung, liver, kidney, skeletal muscle and pancreas. Isoform 4 is expressed in heart, lung, skeletal muscle, kidney and pancreas. Ref.2 Ref.3 Ref.4 Ref.12 Ref.18
Developmental stage: Isoform 1 is expressed in fetal brain. Isoform 2 is expressed in fetal heart, brain, thymus, lung, liver, skeletal muscle, kidney and spleen. Isoform 4 is expressed in fetal heart, brain, thymus, lung and skeletal muscle. Ref.2 Ref.4
Sequence similarities: Belongs to the CELF/BRUNOL family.Contains 3 RRM (RNA recognition motif) domains.
Research Articles on CELF2
Similar Products
Product Notes
The CELF2 celf2 (Catalog #AAA645598) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CUGBP2, CT (CELF2, BRUNOL3, CUGBP2, ETR3, NAPOR, CUGBP Elav-like family member 2, Bruno-like protein 3, CUG triplet repeat RNA-binding protein 2, CUG-BP- and ETR-3-like factor 2, ELAV-type RNA-binding protein 3, Neuroblastoma apoptosis-related RNA-binding reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CUGBP2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the CELF2 celf2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CUGBP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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