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Western Blot (WB) (Western blot analysis of CTNNBL1 in human brain tissue lysate with CTNNBL1 antibody at (A) 1 and (B) 2 ug/mL.)

Rabbit CTTNBL1 Polyclonal Antibody | anti-CTTNBL1 antibody

CTTNBL1 Antibody

Gene Names
CTNNBL1; NAP; P14L; PP8304; C20orf33; dJ633O20.1
Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot
Purity
Affinity chromatography purified via peptide column
Synonyms
CTTNBL1; Polyclonal Antibody; CTTNBL1 Antibody; Beta-catenin-like protein 1; NAP; P14L; PP8304; C20orf33; anti-CTTNBL1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Specificity
CTNNBL1 antibody is predicted to not cross-react with other catenin family members. At least four isoforms of CTNNBL1 are known to exist; this antibody will detect all but isoform b.
Purity/Purification
Affinity chromatography purified via peptide column
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
563
Applicable Applications for anti-CTTNBL1 antibody
ELISA (EIA), Western Blot (WB)
Immunogen Type
Peptide
Immunogen Description
Raised against a 20 amino acid peptide near the carboxy terminus of human CTTNBL1.
Target Name
CTTNBL1
Preparation and Storage
Can be stored at -20 degree C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Western Blot (WB)

(Western blot analysis of CTNNBL1 in human brain tissue lysate with CTNNBL1 antibody at (A) 1 and (B) 2 ug/mL.)

Western Blot (WB) (Western blot analysis of CTNNBL1 in human brain tissue lysate with CTNNBL1 antibody at (A) 1 and (B) 2 ug/mL.)
Related Product Information for anti-CTTNBL1 antibody
The Beta-catenin-like protein 1 (CTNNBL1) contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs, as well as Armadillo/beta-catenin-like repeats. Transient expression of CTNNBL1 resulted in translocation to the nucleus and apoptosis, suggesting it may be involved in the apoptotic pathway. CTNNBL1 interacts with the Prp19 complex of the spliceosome and the Ig class switching enzyme activation-induced deaminase (AID) and had been suggested to play a role in antibody-diversification and class switching, but recent studies have shown CTNNBL1 to be dispensable for Ig class switch recombination. Other studies have identified CTTNBL1 as a novel gene for obesity.
Product Categories/Family for anti-CTTNBL1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
61,971 Da
NCBI Official Full Name
beta-catenin-like protein 1 isoform 1
NCBI Official Synonym Full Names
catenin, beta like 1
NCBI Official Symbol
CTNNBL1
NCBI Official Synonym Symbols
NAP; P14L; PP8304; C20orf33; dJ633O20.1
NCBI Protein Information
beta-catenin-like protein 1
UniProt Protein Name
Beta-catenin-like protein 1
UniProt Gene Name
CTNNBL1
UniProt Synonym Gene Names
C20orf33; NAP
UniProt Entry Name
CTBL1_HUMAN

NCBI Description

The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]

Uniprot Description

CTNNBL1: Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Spliceosome; RNA splicing

Chromosomal Location of Human Ortholog: 20q11.23-q12

Cellular Component: nucleoplasm; spliceosome; membrane; cytoplasm; nucleus

Molecular Function: protein binding; enzyme binding

Biological Process: nuclear mRNA splicing, via spliceosome; somatic diversification of immunoglobulins; apoptosis; positive regulation of apoptosis; RNA splicing; gene expression

Research Articles on CTTNBL1

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Product Notes

The CTTNBL1 ctnnbl1 (Catalog #AAA9401465) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CTTNBL1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CTTNBL1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Researchers should empirically determine the suitability of the CTTNBL1 ctnnbl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CTTNBL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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