CTSD antibody pair

CTSD Antibody Pair

Cat. Num. AAA7041779

• Gene Names: CTSD; CPSD; CLN10; HEL-S-130P
• Reactivity: Bovine, Pig, Dog
• Applications: ELISA
• Synonyms: CTSD; Polyclonal Antibody Pair; CTSD Antibody Pair; Cathepsin D; CPSD; CTSD antibody pair

• Host: Capture: Rabbit; Detection: Rabbit
• Reactivity: Bovine, Pig, Dog
• Clonality: Polyclonal
• Isotype: Capture: IgG; Detection: IgG
• Form/Format: Liquid
• Concentration: The concentrations and volumes of the antibodies may vary and be lot specific. Details will be on the vial labels. (varies by lot)
• Sequence Length: 412

• Applicable Applications for CTSD antibody pair: Sandwich ELISA (EIA)
• Application Notes: We recommend using the capture antibody at a concentration of 0.2ug/ml and the detection antibody at a concentration of 0.2ug/ml.
• Immunogen Species: Human
• Conjugation: Capture: Non-conjugated; Detection: Biotin conjugated
• Recommended Standard: HuH-7 cell; HL-60 cell; HepG2 cell; (Standards are recommendations only. Compatibility of the standards in the user developed application needs to be established and confirmed by the researcher.
• Storage Buffer: Capture: 50% Glycerol, 0.01M PBS, PH 7.4; Detection: 50% Glycerol, 0.01M PBS, PH 7.4
• Other Note: Immunogen information is company proprietary information. Antibodies are sold as a pair and not available separately.
• Preparation and Storage: Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze/thaw cycles. When stored properly, products should be stable for at least 5 months.

NCBI and Uniprot Product Information

• NCBI GI #: 48146011
• NCBI GeneID: 1509
• UniProt Accession #: P07339; Q6IB57
• Molecular Weight: 44,552 Da
• NCBI Official Full Name: CTSD
• NCBI Official Synonym Full Names: cathepsin D
• NCBI Official Symbol: CTSD
• NCBI Official Synonym Symbols: CPSD; CLN10; HEL-S-130P
• NCBI Protein Information: cathepsin D
• UniProt Protein Name: Cathepsin D
• Protein Family: Cathepsin
• UniProt Gene Name: CTSD
• UniProt Synonym Gene Names: CPSD
• UniProt Entry Name: CATD_HUMAN

NCBI Description

This gene encodes a member of the A1 family of peptidases. The encoded preproprotein is proteolytically processed to generate multiple protein products. These products include the cathepsin D light and heavy chains, which heterodimerize to form the mature enzyme. This enzyme exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. [provided by RefSeq, Nov 2015]

Uniprot Description

CTSD: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family.

Protein type: Autophagy; Motility/polarity/chemotaxis; EC 3.4.23.5; Protease

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular matrix; extracellular region; extracellular space; lipid raft; lysosomal lumen; lysosome; melanosome

Molecular Function: aspartic-type endopeptidase activity; cysteine-type endopeptidase activity; protein binding; serine-type endopeptidase activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; autophagy; collagen catabolic process; protein catabolic process; proteolysis

Disease: Ceroid Lipofuscinosis, Neuronal, 10