Rabbit CTNND1 Polyclonal Antibody | anti-CTNND1 antibody

CTNND1 Antibody

Cat. Num. AAA2524951

• Gene Names: CTNND1; CAS; p120; CTNND; P120CAS; P120CTN; p120(CAS); p120(CTN)
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunofluorescence
• Purity: Affinity purification
• Synonyms: CTNND1; Polyclonal Antibody; CTNND1 Antibody; CAS; CTNND; KIAA0384; P120CAS; P120CTN; p120; anti-CTNND1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Sequence Length: 939

• Applicable Applications for anti-CTNND1 antibody: Western Blot (WB), Immunofluorescence (IF)
• Application Notes: Western Blot (WB) 1:500-1:2000; Immunofluorescence (IF) 1:50-1:200
• Immunogen: Recombinant protein of human CTNND1
• Calculated MW: 65-72kDa/90-108kDa
• Observed MW: 105kDa
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1730 / sc-13957
• Preparation and Storage: Store at -20°C. Avoid freeze / thaw cycles.

Western Blot (WB)

(Western blot analysis of extracts of various cell lines with p120 Polyclonal Antibody)

Immunofluorescence (IF)

(Immunofluorescence analysis of U2OS cells with p120 Polyclonal Antibody.)

Related Product Information for anti-CTNND1 antibody

Catenin delta-1 (p120 catenin) has an amino-terminal coiled-coil domain followed by a regulatory domain containing multiple phosphorylation sites and a central Armadillo repeat domain of ten linked 42-amino acid repeats. The carboxy-terminal tail has no known function (1). Catenin delta-1 fulfills critical roles in the regulation of cell-cell adhesion as it regulates E-cadherin turnover at the cell surface to determine the level of E-cadherin available for cell-cell adhesion (2). Catenin delta-1 has both positive and negative effects on cadherin-mediated adhesion (3). Actin dynamics are also regulated by catenin delta-1, which modulates RhoA, Rac, and cdc42 proteins (1). Analogous to beta-catenin, catenin delta-1 translocates to the nucleus, although its role at this location is unclear. Many studies show that catenin delta-1 is expressed irregularly or is absent in various types of tumor cells, suggesting that catenin delta-1 may function as a tumor suppressor (4). Phosphorylation of Tyr904 on Catenin-delta-1 was identified at Cell Signaling Technology (CST) using PhosphoScan, a CST's LC-MS/MS platform for phosphorylation site discovery (5).

NCBI and Uniprot Product Information

• NCBI GI #: 332688210
• NCBI GeneID: 1500
• NCBI Accession #: NP_001193814.1
• NCBI GenBank Nucleotide #: NM_001206885.1
• NCBI Official Full Name: catenin delta-1 isoform 1AC
• NCBI Official Synonym Full Names: catenin (cadherin-associated protein), delta 1
• NCBI Official Symbol: CTNND1
• NCBI Official Synonym Symbols: CAS; p120; CTNND; P120CAS; P120CTN; p120(CAS); p120(CTN)
• NCBI Protein Information: catenin delta-1; cadherin-associated Src substrate; p120 catenin
• UniProt Protein Name: Catenin delta-1
• Protein Family: Catenin
• UniProt Gene Name: CTNND1
• UniProt Synonym Gene Names: KIAA0384; CAS; p120(ctn)
• UniProt Entry Name: CTND1_HUMAN

NCBI Description

This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]

Uniprot Description

CTNND1: an Arm repeat protein that interacts with varied components such as cadherin, small G proteins, kinases, and the Kaiso transcriptional repressor. A downstream modulator of Wnt/beta-catenin signaling pathway whose stability may be regulated downstream of Dsh. Required for the invasiveness of E-cadherin-deficient cells. A signal coordinator between cadherins and Rho-family GTPases to regulate cytoskeletal changes required during dendritic spine and synapse development. The association of catenins with cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Thirty two splice-variant isoforms have been described.

Protein type: Actin-binding; G protein regulator, misc.; Adaptor/scaffold; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 11q11

Cellular Component: growth cone; lamellipodium; cytoplasm; dendritic spine; plasma membrane; synapse; intercellular junction; zonula adherens; midbody; cytosol; nucleus

Molecular Function: protein binding; cadherin binding; protein kinase binding; receptor binding

Biological Process: intercellular junction assembly and maintenance; cell-cell adhesion; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; brain development; cell adhesion; vascular endothelial growth factor receptor signaling pathway