Rabbit anti-Human CTNND1 Polyclonal Antibody | anti-CTNND1 antibody

CTNND1, CT (Catenin delta-1, Cadherin-associated Src Substrate, CAS, p120 Catenin, p120(ctn), p120(cas), KIAA0384)

Cat. Num. AAA647459

• Gene Names: CTNND1; CAS; p120; CTNND; P120CAS; P120CTN; p120(CAS); p120(CTN)
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: CTNND1; Polyclonal Antibody; CT (Catenin delta-1; Cadherin-associated Src Substrate; CAS; p120 Catenin; p120(ctn); p120(cas); KIAA0384); Anti -CTNND1; anti-CTNND1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human P120.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in10mM PBS, pH 7.4, BSA, sodium azide.

• Applicable Applications for anti-CTNND1 antibody: Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry.; Dilution: Immunohistochemistry (Formalin-fixed, paraffin-embedded): 1:15
• Immunogen: Synthetic peptide corresponding to the C-terminal of human P120.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Adrenal (formalin-fixed, paraffin-embedded) stained with CTNND1 antibody at 1:15 followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Immunohistochemistry (IHC)

(Human Spleen, Red Pulp (formalin-fixed, paraffin-embedded) stained with CTNND1 antibody at 1:15 followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-CTNND1 antibody

Catenins are proteins associated with complexes that contain cadherin cell adhesion molecules. Delta-1-catenin is a member of the p120 Catenin subfamily and is a structural protein involved in neuronal development. It interacts with Actin, Cortactin and Src Kinases to promote neurite elongation or branching, depending upon its phosphorylation state. Like beta-catenin and gamma-catenin, delta-catenins appear to interact with presenilins. These catenin-presenilin interactions can impact cadherin function and regulation of cell-to-cell adhesion. While beta-catenin acts as a transcription regulatory protein in the Wnt/TCF pathway, delta-catenin has been implicated as a regulator of the NF-kB transcription factor.

Product Categories/Family for anti-CTNND1 antibody

Antibodies; Abs to Catenin

NCBI and Uniprot Product Information

• NCBI GI #: 49899225
• NCBI GeneID: 1500
• UniProt Accession #: O60716; O15088; O60713; O60714; O60715; O60935; Q6DHZ7; Q6RBX8; Q9UP71; Q9UP72; Q9UP73; A8K939
• Molecular Weight: 108,170 Da
• NCBI Official Full Name: CTNND1 protein
• NCBI Official Synonym Full Names: catenin (cadherin-associated protein), delta 1
• NCBI Official Symbol: CTNND1
• NCBI Official Synonym Symbols: CAS; p120; CTNND; P120CAS; P120CTN; p120(CAS); p120(CTN)
• NCBI Protein Information: catenin delta-1; p120 catenin; cadherin-associated Src substrate
• UniProt Protein Name: Catenin delta-1
• Protein Family: Catenin
• UniProt Gene Name: CTNND1
• UniProt Synonym Gene Names: KIAA0384; CAS; p120(ctn)
• UniProt Entry Name: CTND1_HUMAN

NCBI Description

This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]

Uniprot Description

Function: Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway

By similarity. Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. Ref.17 Ref.26

Subunit structure: Belongs to a multiprotein cell-cell adhesion complex that also contains E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin. Binds to the C-terminal fragment of PSEN1 and mutually competes for E-cadherin. Interacts with ZBTB33. Interacts with GLIS2. Interacts with NANOS1 (via N-terminal region). Interacts with FER. Ref.7 Ref.8 Ref.12 Ref.17 Ref.26

Subcellular location: Cytoplasm. Nucleus Ref.9 Ref.12 Ref.15. Cell membrane. Note: Interaction with GLIS2 promotes nuclear translocation

By similarity. Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm. Isoforms 4A and 1AB are excluded from the nucleus. Ref.9 Ref.12 Ref.15Isoform 1A: Nucleus Ref.9 Ref.12 Ref.15. Isoform 2A: Nucleus Ref.9 Ref.12 Ref.15. Isoform 3A: Nucleus Ref.9 Ref.12 Ref.15.

Tissue specificity: Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs. Ref.9 Ref.11

Induction: Induced in vascular endothelium by wounding. This effect is potentiated by prior laminar shear stress, which enhances wound closure. Ref.11

Domain: A possible nuclear localization signal exists in all isoforms where Asp-626--631-Arg are deleted.ARM repeats 1 to 5 mediate interaction with cadherins.

Post-translational modification: Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK7/PAK5. Dephosphorylated by PTPRJ. Ref.7 Ref.10 Ref.18 Ref.22

Sequence similarities: Belongs to the beta-catenin family.Contains 10 ARM repeats.

Sequence caution: The sequence BAA20838.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.