Rabbit anti-Human CST1 Polyclonal Antibody | anti-CST1 antibody

CST1 Antibody

Cat. Num. AAA9404940

• Reactivity: Human
• Applications: Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: CST1; Polyclonal Antibody; CST1 Antibody; cystain-SA-I; cystatin-1; cystatin-SN; CYTN; salivary cystatin-SA-1; anti-CST1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total CST1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 141

• Applicable Applications for anti-CST1 antibody: Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: Immunohistochemistry: 1:50~1:100; Immunofluorescence: 1:100~1:500
• Immunogen Type: Peptide
• Immunogen Description: Synthesized peptide derived from internal of human CST1.
• Target Name: CST1
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using CST1 antibody.)

Immunofluorescence (IF)

(Immunofluorescence analysis of MCF-7 cells, using CST1 antibody.)

Related Product Information for anti-CST1 antibody

Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well.Deloukas P., Nature 414:865-871(2001).Zhang Z., Protein Sci. 13:2819-2824(2004).Dickinson D.P., DNA Cell Biol. 21:47-65(2002).

Product Categories/Family for anti-CST1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 19882251
• NCBI GeneID: 1469
• NCBI Accession #: NP_001889.2
• NCBI GenBank Nucleotide #: NM_001898.2
• UniProt Accession #: P01037; Q96LE6; Q9UCQ6
• Molecular Weight: 16,388 Da
• NCBI Official Full Name: cystatin-SN
• NCBI Official Synonym Full Names: cystatin SN
• NCBI Official Symbol: CST1
• NCBI Protein Information: cystatin-SN
• UniProt Protein Name: Cystatin-SN
• Protein Family: Cystatin
• UniProt Gene Name: CST1
• UniProt Entry Name: CYTN_HUMAN

NCBI Description

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a cysteine proteinase inhibitor found in saliva, tears, urine, and seminal fluid. [provided by RefSeq, Jul 2008]

Uniprot Description

CST1: Human saliva appears to contain several cysteine proteinase inhibitors that are immunologically related to cystatin S but that differ in their specificity due to amino acid sequence differences. Cystatin SN, with a pI of 7.5, is a much better inhibitor of papain and dipeptidyl peptidase I than is cystatin S, although both inhibit ficin equally well. Belongs to the cystatin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20p11.21

Cellular Component: extracellular space

Molecular Function: cysteine protease inhibitor activity

Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste