Rabbit CSRP3 Polyclonal Antibody | anti-CSRP3 antibody

CSRP3 Polyclonal Antibody

Cat. Num. AAA3008314

• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: CSRP3; Polyclonal Antibody; CSRP3 Polyclonal Antibody; Cysteine and glycine-rich protein 3; Cardiac LIM protein; Cysteine-rich protein 3; CRP3; LIM domain protein; cardiac; Muscle LIM protein; CLP; MLP; anti-CSRP3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CSRP3 polyclonal antibody detects endogenous levels of CSRP3 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 194

• Applicable Applications for anti-CSRP3 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: Recombinant full length Human CSRP3.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of CSRP3 polyclonal antibody)

Related Product Information for anti-CSRP3 antibody

Cysteine and glycine-rich protein 3 (CRP3), also known as cysteine-rich protein 3, CLP (cardiac LIM protein), MLP (muscle LIM protein), LMO4 or CMD1M, is an essential nuclear regulator of myogenic differentiation. CRP3 contains two LIM zinc-binding domains linked to short glycine-rich repeats and a potential nuclear localization signal. CRP3 is present in differentiated heart during early development and in a subset of other striated muscles during later stages. Defects in the gene encoding CRP3 (CSRP3) can cause dilated cardiomyopathy 1M (CMD1M), a disease characterized by reduced systolic functionand cardiac dilation. Human CSRP3 maps to the gene locus 11p15.1.

NCBI and Uniprot Product Information

• NCBI GI #: 1705933
• UniProt Accession #: P50461
• Molecular Weight: ~ 21kDa
• NCBI Official Full Name: Cysteine and glycine-rich protein 3
• UniProt Protein Name: Cysteine and glycine-rich protein 3
• Protein Family: Cysteine and glycine-rich protein
• UniProt Gene Name: CSRP3
• UniProt Synonym Gene Names: CLP; MLP; CRP3
• UniProt Entry Name: CSRP3_HUMAN

Uniprot Description

CSRP3: Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. Defects in CSRP3 are the cause of cardiomyopathy dilated type 1M (CMD1M). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in CSRP3 are the cause of familial hypertrophic cardiomyopathy type 12 (CMH12). Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 11p15.1

Cellular Component: cytoskeleton; nucleus; Z disc

Molecular Function: actinin binding; protein binding; telethonin binding; zinc ion binding; structural constituent of muscle

Biological Process: cardiac muscle development; cellular calcium ion homeostasis; skeletal muscle development; protein localization in organelle; cardiac myofibril assembly; positive regulation of transcription from RNA polymerase II promoter; regulation of the force of heart contraction; cardiac muscle contraction

Disease: Cardiomyopathy, Familial Hypertrophic, 12; Cardiomyopathy, Dilated, 1m