Western Blot (WB)
(Western blot analysis of extracts from Mouse brain, using CRMP4 Antibody. The lane on the left was treated with blocking peptide.)
Rabbit CRMP4 Polyclonal Antibody | anti-CRMP4 antibody
CRMP4 Antibody
Gene Names
DPYSL3; DRP3; ULIP; CRMP4; DRP-3; LCRMP; CRMP-4; ULIP-1
Reactivity
Human, Mouse, RatPredicted: Bovine, Horse, Rabbit, Dog
Applications
Western Blot
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
CRMP4; Polyclonal Antibody; CRMP4 Antibody; Collapsin response mediator protein 4; Collapsin response mediator protein 4 long; CRMP 4; CRMP-4; Dihydropyrimidinase like 3; Dihydropyrimidinase related protein 3; Dihydropyrimidinase-related protein 3; DPYL3_HUMAN; DPYSL3; DRP 3; DRP-3; DRP3; LCRMP; TUC4; ULIP 1; ULIP; ULIP-1; ULIP1; UNc 33 like phosphoprotein 1; Unc 33 like phosphoprotein; Unc-33-like phosphoprotein 1; anti-CRMP4 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Predicted: Bovine, Horse, Rabbit, Dog
Predicted: Bovine, Horse, Rabbit, Dog
Clonality
Polyclonal
Isotype
IgG
Specificity
CRMP4 Antibody detects endogenous levels of CRMP4.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
684
Applicable Applications for anti-CRMP4 antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:2000
Immunogen
A synthesized peptide derived from human CRMP4.
Tissue Specificity
Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.
Fragment
Fab Fragment
Conjugate
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis of extracts from Mouse brain, using CRMP4 Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from Mouse brain, using CRMP4 Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from Jurkat cells, using CRMP4 Antibody. The lane on the left was treated with blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from Jurkat cells, using CRMP4 Antibody. The lane on the left was treated with blocking peptide.)
Related Product Information for anti-CRMP4 antibody
Description: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
Post Translational Modifications: Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
Subunit Structure: Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5. Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin.
Similarity: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
Post Translational Modifications: Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
Subunit Structure: Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5. Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin.
Similarity: Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Observed: 62 kDa
Predicted: 62 kDa
Predicted: 62 kDa
NCBI Official Full Name
dihydropyrimidinase-related protein 3 isoform 1
NCBI Official Synonym Full Names
dihydropyrimidinase like 3
NCBI Official Symbol
DPYSL3
NCBI Official Synonym Symbols
DRP3; ULIP; CRMP4; DRP-3; LCRMP; CRMP-4; ULIP-1
NCBI Protein Information
dihydropyrimidinase-related protein 3
UniProt Protein Name
Dihydropyrimidinase-related protein 3
UniProt Gene Name
DPYSL3
UniProt Synonym Gene Names
CRMP4; DRP3; ULIP; ULIP1; DRP-3; CRMP-4; ULIP-1
UniProt Entry Name
DPYL3_HUMAN
Uniprot Description
CRMP-4: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase
Chromosomal Location of Human Ortholog: 5q32
Cellular Component: filamentous actin; extracellular space; growth cone; lamellipodium; cytosol
Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides; phosphoprotein binding; SH3 domain binding
Biological Process: actin crosslink formation; positive regulation of filopodium formation; axon guidance; actin filament bundle formation; response to axon injury; negative regulation of cell migration; pyrimidine base catabolic process; protein homooligomerization
Research Articles on CRMP4
Similar Products
Product Notes
The CRMP4 dpysl3 (Catalog #AAA9611667) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CRMP4 Antibody reacts with Human, Mouse, Rat Predicted: Bovine, Horse, Rabbit, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's CRMP4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the CRMP4 dpysl3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CRMP4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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