Rabbit CRIM1 Polyclonal Antibody | anti-CRIM1 antibody

CRIM1 Polyclonal Antibody

Cat. Num. AAA2518579

• Gene Names: CRIM1; S52; CRIM-1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: CRIM1; Polyclonal Antibody; CRIM1 Polyclonal Antibody; S52; CRIM-1; anti-CRIM1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.8mg/mL (varies by lot)
• Sequence Length: 1036

• Applicable Applications for anti-CRIM1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Synthetic peptide of human CRIM1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using CRIM1 Polyclonal Antibody at dilution 1:25)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CRIM1 Polyclonal Antibody at dilution 1:25)

Related Product Information for anti-CRIM1 antibody

This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins.

NCBI and Uniprot Product Information

• NCBI GI #: 10092639
• NCBI GeneID: 51232
• NCBI Accession #: NP_057525.1
• NCBI GenBank Nucleotide #: NM_016441.2
• Molecular Weight: 113,738 Da
• NCBI Official Full Name: cysteine-rich motor neuron 1 protein
• NCBI Official Synonym Full Names: cysteine rich transmembrane BMP regulator 1 (chordin-like)
• NCBI Official Symbol: CRIM1
• NCBI Official Synonym Symbols: S52; CRIM-1
• NCBI Protein Information: cysteine-rich motor neuron 1 protein; cysteine-rich repeat-containing protein S52
• UniProt Protein Name: Cysteine-rich motor neuron 1 protein
• Protein Family: Cysteine-rich motor neuron 1 protein
• UniProt Gene Name: CRIM1
• UniProt Synonym Gene Names: S52; CRIM-1
• UniProt Entry Name: CRIM1_HUMAN

NCBI Description

This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]

Uniprot Description

CRIM1: May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p21

Cellular Component: integral to membrane; plasma membrane

Molecular Function: serine-type endopeptidase inhibitor activity; insulin-like growth factor binding; insulin-like growth factor receptor activity; PDZ domain binding

Biological Process: nervous system development; insulin-like growth factor receptor signaling pathway; regulation of cell growth