Rabbit anti-Human CRHBP  Polyclonal Antibody | anti-CRHBP  antibody

CRHBP  Polyclonal Antibody

Cat. Num. AAA2536587

• Gene Names: CRHBP; CRFBP; CRF-BP
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: Affinity Purification
• Synonyms: CRHBP ; Polyclonal Antibody; CRHBP Polyclonal Antibody; CRFBP; CRF-BP; anti-CRHBP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purification

• Applicable Applications for anti-CRHBP antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000, IHC: 1:50-1:200, IF: 1:50-1:100
• Immunogen: Recombinant protein of human CRHBP
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Western Blot (WB)

(Western blot analysis of extracts of various cells, using CRHBP antibody.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse heart using CRHBP antibody at dilution of1:100 (40x lens).)

Immunofluorescence (IF3)

(Immunofluorescence analysis of HeLa cell using CRHBP antibody. Blue: DAPI for nuclear staining.)

Related Product Information for anti-CRHBP  antibody

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy.

NCBI and Uniprot Product Information

• NCBI GI #: 47080099
• NCBI GeneID: 1393
• NCBI Accession #: NP_001873.2
• NCBI GenBank Nucleotide #: NM_001882.3
• Molecular Weight: Calculated MW: 36kDa
• NCBI Official Full Name: corticotropin-releasing factor-binding protein
• NCBI Official Synonym Full Names: corticotropin releasing hormone binding protein
• NCBI Official Symbol: CRHBP
• NCBI Official Synonym Symbols: CRFBP; CRF-BP
• NCBI Protein Information: corticotropin-releasing factor-binding protein
• UniProt Protein Name: Corticotropin-releasing factor-binding protein
• UniProt Gene Name: CRHBP
• UniProt Synonym Gene Names: CRFBP; CRF-BP; CRF-binding protein; CRH-BP
• UniProt Entry Name: CRHBP_HUMAN

NCBI Description

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]

Uniprot Description

CRHBP: Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.

Protein type: Secreted, signal peptide; Secreted; Inhibitor

Chromosomal Location of Human Ortholog: 5q13.3

Cellular Component: dendrite; endoplasmic reticulum; extracellular space; Golgi apparatus; intracellular; microtubule; multivesicular body; nerve terminal; nucleus; perikaryon; secretory granule

Molecular Function: corticotropin-releasing hormone binding; peptide binding; protein binding

Biological Process: behavioral response to ethanol; cellular response to stress; female pregnancy; hormone metabolic process; hormone-mediated signaling; inflammatory response; learning and/or memory; negative regulation of adrenocorticotropic hormone secretion; regulated secretory pathway; regulation of adrenocorticotropin hormone secretion; signal transduction; synaptic transmission, dopaminergic