Rabbit CRFR1 / CRHR1 Polyclonal Antibody | anti-CRFR1 antibody

Rabbit Polyclonal to Human CRFR1 / CRHR1

Cat. Num. AAA247197

• Gene Names: CRHR1; CRF1; CRHR; CRF-R; CRFR1; CRF-R1; CRFR-1; CRH-R1; CRHR1L; CRF-R-1; CRH-R-1
• Reactivity: Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Pig, Sheep; Predicted Reactivity: Bat (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: CRFR1 / CRHR1; Polyclonal Antibody; Rabbit Polyclonal to Human CRFR1 / CRHR1; Anti-CRFR1 / CRHR1 Antibody (Extracellular Domain) IHC-plus; CRHR1; CRF-R-1; CRFR; CRHR1f; Crf receptor 1; CRH-R1; CRF-R; CRF1; CRFR-1; Crf receptor type 1; Crf type 1; CRF-R1; Crf1 receptor; CRFR1; CRH-R-1; CRH-R1h; CRHR; CRHR1L; Human CRFR1; anti-CRFR1 antibody

• Host: Rabbit
• Reactivity: Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Pig, Sheep; Predicted Reactivity: Bat (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human CRF1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 444

• Applicable Applications for anti-CRFR1 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (20 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from 1st extracellular domain of human CRF1. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Sheep, Hamster, Dog, Bovine, Horse, Pig, Opossum (100%); Elephant, Panda, Bat (94%).
• Immunogen Type: Synthetic peptide
• Immunogen: CRFR1 / CRHR1 antibody was raised against synthetic 18 amino acid peptide from 1st extracellular domain of human CRF1. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Sheep, Hamster, Dog, Bovine, Horse, Pig, Opossum (100%); Elephant, Panda, Bat (94%); Marmoset, Mouse, Rat, Seabass, Stickleback, Pufferfish (89%); Turkey, Chicken, Lizard, Zebrafish (83%).
• Antigen Modification: Extracellular Domain
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-CRFR1 / CRHR1 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-CRFR1 / CRHR1 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-CRFR1 / CRHR1 antibody IHC of human brain, putamen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-CRF1 antibody IHC of human pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-CRFR1 / CRHR1 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-CRFR1 antibody

Corticotropin-releasing factor receptor 1 (CRFR1/CRHR1), a Corticotropin-Releasing Factor Receptor, is involved in mediating the stress response and anxiety-related behaviors. Mutations of the receptor reduce anxiety-related behaviors and may be involved in the pathogenesis of Cushing disease. Multiple isoforms of CRFR1 are produced by alternative splicing.

Product Categories/Family for anti-CRFR1 antibody

Family: GPCR; Subfamily: Corticotropin releasing factor

NCBI and Uniprot Product Information

• NCBI GI #: 223717971
• NCBI GeneID: 1394
• NCBI Accession #: NP_001138618.1
• NCBI GenBank Nucleotide #: NM_001145146.1
• UniProt Accession #: P34998; Q13008; Q4QRJ1; Q9UK64; B4DIE9
• Molecular Weight: 28,122 Da
• NCBI Official Full Name: corticotropin-releasing factor receptor 1 isoform 1
• NCBI Official Synonym Full Names: corticotropin releasing hormone receptor 1
• NCBI Official Symbol: CRHR1
• NCBI Official Synonym Symbols: CRF1; CRHR; CRF-R; CRFR1; CRF-R1; CRFR-1; CRH-R1; CRHR1L; CRF-R-1; CRH-R-1
• NCBI Protein Information: corticotropin-releasing factor receptor 1; CRH receptor 1; seven transmembrane helix receptor; corticotropin-releasing factor type 1 receptor
• UniProt Protein Name: Corticotropin-releasing factor receptor 1
• UniProt Gene Name: CRHR1
• UniProt Synonym Gene Names: CRFR; CRFR1; CRHR; CRF-R-1; CRF-R1; CRFR-1; CRH-R-1; CRH-R1
• UniProt Entry Name: CRFR1_HUMAN

NCBI Description

This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and upstream GeneID:401884 (ADP-ribosylation factor 3 pseudogene), and the readthrough transcripts encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Dec 2014]

Uniprot Description

CRF-R1: a G-protein coupled receptor that specifically binds corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. Four splice-variant isoforms have been described.

Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: multivesicular body; cell soma; integral to plasma membrane; apical part of cell; dendrite; plasma membrane; integral to membrane; trans-Golgi network; intrinsic to plasma membrane; vesicle

Molecular Function: protein binding; corticotropin-releasing hormone binding; corticotropin-releasing hormone receptor activity; protein complex binding; G-protein alpha-subunit binding; corticotrophin-releasing factor receptor activity

Biological Process: fear response; hypothalamus development; hormone-mediated signaling; adrenal gland development; adenylate cyclase activation; positive regulation of mast cell degranulation; behavioral response to ethanol; female pregnancy; memory; behavioral response to pain; general adaptation syndrome, behavioral process; elevation of cytosolic calcium ion concentration; epithelial cell differentiation; adrenocorticotropin hormone secretion; behavioral response to cocaine; neuropeptide signaling pathway; response to hypoxia; negative regulation of epinephrine secretion; visual learning; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); immune response; parturition; response to electrical stimulus