Immunohistochemistry (IHC)
(Anti-COX1 Picoband antibody, MBS176993-1.JPGIHC(P): Human Intestinal Cancer Tissue )
Rabbit anti-Human, Rat COX1 Polyclonal Antibody | anti-PTGS1 antibody
Anti-COX1 antibody
Immunohistochemistry (IHC)
(Anti-COX1 Picoband antibody, MBS176993-1.JPGIHC(P): Human Intestinal Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-COX1 Picoband antibody, MBS176993-1.JPGIHC(P): Human Intestinal Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-COX1 Picoband antibody, MBS176993-2.JPGIHC(P): Human Lung Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-COX1 Picoband antibody, MBS176993-2.JPGIHC(P): Human Lung Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-COX1 Picoband antibody, MBS176993-3.JPGIHC(P): Rat Intestine Tissue )
Immunohistochemistry (IHC)
(Anti-COX1 Picoband antibody, MBS176993-3.JPGIHC(P): Rat Intestine Tissue )
Immunohistochemistry (IHC)
(Anti-COX1 Picoband antibody, MBS176993-4.JPGIHC(P): Human Mammary Cancer Tissue )
Immunohistochemistry (IHC)
(Anti-COX1 Picoband antibody, MBS176993-4.JPGIHC(P): Human Mammary Cancer Tissue )
Testing Data
(Anti-COX1 Picoband antibody, MBS176993-5.jpgAll lanes: Anti-COX1(MBS176993) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 40ugLane 2: HELA Whole Cell Lysate at 40ugLane 3: JURKAT Whole Cell Lysate at 40ugLane 4: K562 Whole Cell Lysate at 40ugLane 5: MCF-7 Whole Cell Lysate at 40ugLane 6: A549 Whole Cell Lysate at 40ugPredicted bind size: 69KDObserved bind size: 69KD )
Testing Data
(Anti-COX1 Picoband antibody, MBS176993-5.jpgAll lanes: Anti-COX1(MBS176993) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 40ugLane 2: HELA Whole Cell Lysate at 40ugLane 3: JURKAT Whole Cell Lysate at 40ugLane 4: K562 Whole Cell Lysate at 40ugLane 5: MCF-7 Whole Cell Lysate at 40ugLane 6: A549 Whole Cell Lysate at 40ugPredicted bind size: 69KDObserved bind size: 69KD )
Background: Cyclooxygenase 1(COX1), also known as Prostaglandin-endoperoxide synthase (PTGS1) or mitochondrial cytochrome c oxidase subunit 1, is the key enzyme in prostaglandin biosynthesis. The gene was approximately 40 kb long, with 11 protein-coding exons. There were 599 amino acid residues with a calculated molecular mass of approximately 68 kD. By analysis of a human/hamster somatic hybrid DNA panel, it was demonstrated that the PTGS1 gene maps to chromosome 9. Human prostaglandin endoperoxide synthase exhibited 91% amino acid identity with the sheep enzyme. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.
NCBI and Uniprot Product Information
NCBI Description
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Uniprot Description
COX-1: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.99.1; Lipid Metabolism - arachidonic acid; Oxidoreductase
Chromosomal Location of Human Ortholog: 9q32-q33.3
Cellular Component: endoplasmic reticulum membrane; photoreceptor outer segment; intracellular membrane-bound organelle; cytoplasm; nucleus
Molecular Function: prostaglandin-endoperoxide synthase activity; peroxidase activity; dioxygenase activity; metal ion binding; heme binding
Biological Process: regulation of blood pressure; xenobiotic metabolic process; cyclooxygenase pathway; arachidonic acid metabolic process; response to oxidative stress; lipid metabolic process; prostaglandin biosynthetic process; inflammatory response; regulation of cell proliferation
Research Articles on PTGS1
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Product Notes
The PTGS1 ptgs1 (Catalog #AAA176993) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-COX1 antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's COX1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Researchers should empirically determine the suitability of the PTGS1 ptgs1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COX1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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