Rabbit anti-Human Corticotrophin Releasing Factor Polyclonal Antibody | anti-CRHR1 antibody

Corticotrophin Releasing Factor, CT (Corticotropin-releasing Factor, CRF, Corticoliberin, Corticotropin Releasing Hormone, CRH)

Cat. Num. AAA6007057

• Gene Names: CRHR1; CRF1; CRHR; CRF-R; CRFR1; CRF-R1; CRFR-1; CRH-R1; CRHR1L; CRHR1f; CRF-R-1; CRH-R-1; CRH-R1h
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Corticotrophin Releasing Factor; Polyclonal Antibody; CT (Corticotropin-releasing Factor; CRF; Corticoliberin; Corticotropin Releasing Hormone; CRH); Anti -Corticotrophin Releasing Factor; anti-CRHR1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human CRH. Species sequence homology: mouse and rat
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in 10mM PBS, pH 7.4, BSA, sodium azide.

• Applicable Applications for anti-CRHR1 antibody: Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry.; Dilution: Immunohistochemistry (Formalin-fixed, paraffin-embedded): 20ug/ml
• Immunogen: Synthetic peptide corresponding to the C-terminal of human CRF protein.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Placenta (formalin-fixed, paraffin-embedded) stained with CRH antibody at 20ug/ml followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-CRHR1 antibody

Corticotropin-releasing hormone (CRH) is a 41aa peptide derived from a 191aa preprohormone. CRH is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in CRH has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, CRH is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta CRH is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of CRH occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, CRH may act as a trigger for parturition.

Product Categories/Family for anti-CRHR1 antibody

Antibodies; Abs to Hormones; Steroids

NCBI and Uniprot Product Information

• NCBI GI #: 223717971
• NCBI GeneID: 1394
• NCBI Accession #: NP_001138618.1
• NCBI GenBank Nucleotide #: NM_001145146.1
• UniProt Accession #: P34998; Q13008; Q4QRJ1; Q9UK64; B4DIE9
• Molecular Weight: 50,719 Da
• NCBI Official Full Name: corticotropin-releasing factor receptor 1 isoform 1
• NCBI Official Synonym Full Names: corticotropin releasing hormone receptor 1
• NCBI Official Symbol: CRHR1
• NCBI Official Synonym Symbols: CRF1; CRHR; CRF-R; CRFR1; CRF-R1; CRFR-1; CRH-R1; CRHR1L; CRHR1f; CRF-R-1; CRH-R-1; CRH-R1h
• NCBI Protein Information: corticotropin-releasing factor receptor 1; seven transmembrane helix receptor; corticotropin-releasing hormone receptor 1; corticotropin-releasing factor type 1 receptor; corticotropin releasing hormone receptor variant 1e; corticotropin releasing hormone receptor variant 1g
• UniProt Protein Name: Corticotropin-releasing factor receptor 1
• Protein Family: Corticotropin-releasing factor receptor
• UniProt Gene Name: CRHR1
• UniProt Synonym Gene Names: CRFR; CRFR1; CRHR; CRF-R-1; CRF-R1; CRFR-1; CRH-R-1; CRH-R1
• UniProt Entry Name: CRFR1_HUMAN

NCBI Description

This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants, one of which represents a read-through transcript with the neighboring gene MGC57346. [provided by RefSeq, Jan 2012]

Uniprot Description

CRF-R1: a G-protein coupled receptor that specifically binds corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. Four splice-variant isoforms have been described.

Protein type: Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: multivesicular body; cell soma; apical part of cell; integral to plasma membrane; dendrite; plasma membrane; integral to membrane; trans-Golgi network; intrinsic to plasma membrane; vesicle

Molecular Function: protein binding; corticotropin-releasing hormone binding; corticotropin-releasing hormone receptor activity; protein complex binding; G-protein alpha-subunit binding; corticotrophin-releasing factor receptor activity

Biological Process: fear response; hypothalamus development; hormone-mediated signaling; adrenal gland development; adenylate cyclase activation; positive regulation of mast cell degranulation; female pregnancy; behavioral response to ethanol; memory; general adaptation syndrome, behavioral process; elevation of cytosolic calcium ion concentration; behavioral response to pain; epithelial cell differentiation; adrenocorticotropin hormone secretion; behavioral response to cocaine; neuropeptide signaling pathway; negative regulation of epinephrine secretion; response to hypoxia; visual learning; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); immune response; parturition; response to electrical stimulus