Western Blot (WB)
((0.1ug/ml) staining of Human Skin lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Goat Copine 1 Polyclonal Antibody | anti-CPNE1 antibody
Goat anti-Copine 1 Antibody
Western Blot: Approx 55kDa band observed in Human Skin lysates (calculated MW of 59.1kDa according to NP_690902.1). Recommended concentration: 0.1-0.3ug/ml.
Western Blot (WB)
((0.1ug/ml) staining of Human Skin lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Western Blot (WB)
((0.1ug/ml) staining of Human Skin lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Alternate splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Aug 2008]
Uniprot Description
CPNE1: May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties. Belongs to the copine family.
Protein type: Lipid-binding
Chromosomal Location of Human Ortholog: 20q11.22
Cellular Component: cytoplasm; cytosol; membrane; nucleus; plasma membrane
Molecular Function: calcium ion binding; calcium-dependent phospholipid binding; endopeptidase activity; NF-kappaB binding; phosphatidylserine binding; protein binding; protein homodimerization activity; transporter activity
Biological Process: glycerophospholipid biosynthetic process; lipid metabolic process; negative regulation of DNA binding; positive regulation of neuron differentiation; positive regulation of protein kinase B signaling cascade; proteolysis; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of transcription, DNA-dependent; transcription, DNA-dependent; vesicle-mediated transport
Research Articles on CPNE1
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Product Notes
The CPNE1 cpne1 (Catalog #AAA422263) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-Copine 1 Antibody reacts with Tested: Human; Expected from sequence similarity: Human, Cow, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's Copine 1 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Western Blot (WB). Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Approx 55kDa band observed in Human Skin lysates (calculated MW of 59.1kDa according to NP_690902.1). Recommended concentration: 0.1-0.3ug/ml. Researchers should empirically determine the suitability of the CPNE1 cpne1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: APLKPLPPSA KDPA. It is sometimes possible for the material contained within the vial of "Copine 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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