Goat Connexin 30/GJB6 Polyclonal Antibody | anti-GJB6 antibody
Goat anti-Connexin 30/GJB6 Antibody
Western Blot: Preliminary experiments gave an approx 14kDa band in Human Brain (Cerebellum) and Rat Brain lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 30.4kDa according to NP_006774.2. The 14kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI and Uniprot Product Information
NCBI Description
Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008]
Uniprot Description
GJB6: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Belongs to the connexin family. Beta-type (group I) subfamily. A connexon is composed of a hexamer of connexins. Interacts with CNST
Protein type: Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 13q12
Cellular Component: apical plasma membrane; cell junction; connexon complex; cytosol; integral to membrane
Biological Process: aging; apoptosis; cell communication; ear morphogenesis; inner ear development; negative regulation of cell proliferation; response to electrical stimulus; response to lipopolysaccharide; sensory perception of sound
Disease: Clouston Syndrome; Deafness, Autosomal Dominant 3b; Deafness, Autosomal Recessive 1a; Deafness, Autosomal Recessive 1b; Deafness, X-linked 2
Research Articles on GJB6
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Product Notes
The GJB6 gjb6 (Catalog #AAA421867) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-Connexin 30/GJB6 Antibody reacts with Expected from sequence similarity: Human, Mouse, Rat, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's Connexin 30/GJB6 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 16000. Western Blot: Preliminary experiments gave an approx 14kDa band in Human Brain (Cerebellum) and Rat Brain lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 30.4kDa according to NP_006774.2. The 14kDa band was successfully blocked by incubation with the immunizing peptide. Researchers should empirically determine the suitability of the GJB6 gjb6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: RSKRAQTQKN HPNH. It is sometimes possible for the material contained within the vial of "Connexin 30/GJB6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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