Western Blot (WB)
(Western Blot: Sample: Human Serum.)
Rabbit anti-Human Complement Component 6 Polyclonal Antibody | anti-C6 antibody
Polyclonal Antibody to Complement Component 6 (C6)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGS- QYFRCLPDG TWRQGDVECQ RTECIKPVVQ EVLTITPFQR LYRIGESIEL TCPKGFVVAG PSRYTCQGNS WTPPISNSLT CEKDTLTKLK GHCQLGQKQS GSECICMSPE EDCSHHSEDL CVFDTDSNDY FTSPACKFLA EKCLNNQQLH FLHIGSCQDG RQLEWGLERT RLSSNSTKKE SCGYDTCYDW EKCSASTSKC VCLLPPQCFK GGNQLYCVKM GSSTSEKTLN ICEVGTIRCA NRKMEILHPG KCLA
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Human Serum.)
Western Blot (WB)
(Western Blot: Sample: Human Serum.)
Western Blot (WB)
(Western Blot: Sample: Recombinant C6, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant C6, Human.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Glioma Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Glioma Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Lung Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Lung Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Brain Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Brain Tissue)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]
Uniprot Description
C6: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C6 are the cause of complement component 6 deficiency (C6D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 5p13.1
Cellular Component: extracellular region; membrane attack complex
Molecular Function: protein binding
Biological Process: complement activation; complement activation, classical pathway; cytolysis; in utero embryonic development; innate immune response; positive regulation of activation of membrane attack complex; positive regulation of angiogenesis; regulation of complement activation
Disease: Complement Component 6 Deficiency
Research Articles on C6
Similar Products
Product Notes
The C6 c6 (Catalog #AAA2026847) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Complement Component 6 (C6) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Complement Component 6 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 0.5-5ug/mL Immunohistochemistry: 5-20ug/mL Immunocytochemistry: 5-20ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the C6 c6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGS- QYFRCLPDG TWRQGDVECQ RTECIKPVVQ EVLTITPFQR LYRIGESIEL TCPKGFVVAG PSRYTCQGNS WTPPISNSLT CEKDTLTKLK GHCQLGQKQS GSECICMSPE EDCSHHSEDL CVFDTDSNDY FTSPACKFLA EKCLNNQQLH FLHIGSCQDG RQLEWGLERT RLSSNSTKKE SCGYDTCYDW EKCSASTSKC VCLLPPQCFK GGNQLYCVKM GSSTSEKTLN ICEVGTIRCA NRKMEILHPG KCLA. It is sometimes possible for the material contained within the vial of "Complement Component 6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
