Rabbit anti-Human Complement, C1q Polyclonal Antibody | anti-C1QC antibody

Complement, C1q, Human

Cat. Num. AAA627016

• Gene Names: C1QC; C1QG; C1Q-C
• Reactivity: Human
• Applications: ELISA, immunoassay, Radioimmunoassay
• Purity: Serum; Serum
• Synonyms: Complement; C1q; Polyclonal Antibody; Human; Anti -Complement; anti-C1QC antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human C1Q: 100%.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid.

• Applicable Applications for anti-C1QC antibody: ELISA (EL/EIA), Radioimmunoassay (RIA)
• Application Notes: Suitable for ELISA or RIA.; Dilution: RIA: 20,000 tests/ml
• Immunogen: Human C1Q
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-C1QC antibody

C1q is serum glycoprotein of 18-polypeptides chains consisting of three non-identical subunits, A (29kD), B (26kD) and C (246aa, 19kD) in molar ratio of 1:2:2. C1Q in the plasma is complexed with two proenzymes C1r and two C1s molecules to form the first component of complement (C1). Activation of complement via classical pathway is triggered by binding of globular head of C1q to immune complexes containing IgG (Fc-region) or IgM or to a variety of other activating substances, including C-reactive protein, retrovirus and mitochondria. Subsequent to C1q binding, c1r and C1s are converted to proteolytic enzymes that are responsible to continuation of activation via the classical pathway. Normal plasma concentration of C1q is 100-180mg/L.

Product Categories/Family for anti-C1QC antibody

Antibodies; Abs to Complement

NCBI and Uniprot Product Information

• NCBI GI #: 166235903
• NCBI GeneID: 714
• NCBI Accession #: NP_001107573.1
• NCBI GenBank Nucleotide #: NM_001114101.1
• UniProt Accession #: P02747; Q7Z502; Q96DL2; Q96H05
• Molecular Weight: 25,774 Da
• NCBI Official Full Name: complement C1q subcomponent subunit C
• NCBI Official Synonym Full Names: complement component 1, q subcomponent, C chain
• NCBI Official Symbol: C1QC
• NCBI Official Synonym Symbols: C1QG; C1Q-C
• NCBI Protein Information: complement C1q subcomponent subunit C; complement component 1, q subcomponent, gamma polypeptide
• UniProt Protein Name: Complement C1q subcomponent subunit C
• Protein Family: Complement C1q subcomponent
• UniProt Gene Name: C1QC
• UniProt Synonym Gene Names: C1QG
• UniProt Entry Name: C1QC_HUMAN

NCBI Description

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

C1QC: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Defects in C1QC are a cause of complement component C1q deficiency (C1QD). A rare defect resulting in C1 deficiency and impaired activation of the complement classical pathway. C1 deficiency generally leads to severe immune complex disease with features of systemic lupus erythematosus and glomerulonephritis.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: extracellular space; collagen; extracellular region

Biological Process: negative regulation of macrophage differentiation; innate immune response; immune response; complement activation, classical pathway; complement activation; negative regulation of granulocyte differentiation

Disease: C1q Deficiency