Rabbit anti-Mouse COL9A3 Polyclonal Antibody | anti-COL9A3 antibody

COL9A3 Polyclonal Antibody

Cat. Num. AAA9434569

• Gene Names: COL9A3; IDD; MED; EDM3; DJ885L7.4.1
• Reactivity: Mouse
• Applications: Immunohistochemistry
• Purity: Affinity purification
• Synonyms: COL9A3; Polyclonal Antibody; COL9A3 Polyclonal Antibody; DJ885L7.4.1; EDM3; IDD; MED; collagen alpha-3 (IX) chain; anti-COL9A3 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 50% glycerol, pH7.4

• Applicable Applications for anti-COL9A3 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:100-1:200
• Immunogen: Recombinant fusion protein of human COL9A3 (NP_001844.3).
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded mouse heart using COL9A3 antibody.)

Related Product Information for anti-COL9A3 antibody

This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. Mutations in this gene are associated with multiple epiphyseal dysplasia type 3.

Product Categories/Family for anti-COL9A3 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 119508426
• NCBI GeneID: 1299
• NCBI Accession #: NP_001844.3
• NCBI GenBank Nucleotide #: NM_001853.3
• UniProt Accession #: Q14050; Q13681; Q9H4G9; Q9UPE2
• Molecular Weight: 63,616 Da
• NCBI Official Full Name: collagen alpha-3(IX) chain
• NCBI Official Synonym Full Names: collagen, type IX, alpha 3
• NCBI Official Symbol: COL9A3
• NCBI Official Synonym Symbols: IDD; MED; EDM3; DJ885L7.4.1
• NCBI Protein Information: collagen alpha-3(IX) chain; collagen alpha-3(IX) chain; collagen type IX proteoglycan; collagen IX, alpha-3 polypeptide
• UniProt Protein Name: Collagen alpha-3(IX) chain
• Protein Family: Collagen
• UniProt Gene Name: COL9A3
• UniProt Entry Name: CO9A3_HUMAN

NCBI Description

This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. Mutations in this gene are associated with multiple epiphyseal dysplasia type 3. [provided by RefSeq, Jan 2010]

Uniprot Description

COL9A3: Structural component of hyaline cartilage and vitreous of the eye. Defects in COL9A3 are the cause of multiple epiphyseal dysplasia type 3 (EDM3); also known as multiple epiphyseal dysplasia with myopathy. EDM is a generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. EDM is broadly categorized into the more severe Fairbank and the milder Ribbing types. Defects in COL9A3 are a cause of susceptibility to intervertebral disk disease (IDD). A common musculo- skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. Susceptibility to intervertebral disk disease, is conferred by variant p.Arg103Trp (PubMed:11308397). Belongs to the fibril-associated collagens with interrupted helices (FACIT) family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum lumen; extracellular region

Molecular Function: extracellular matrix structural constituent conferring tensile strength

Biological Process: extracellular matrix disassembly; axon guidance; collagen catabolic process; extracellular matrix organization and biogenesis; male gonad development; female gonad development

Disease: Epiphyseal Dysplasia, Multiple, 3; Intervertebral Disc Disease