Rabbit anti-Human COL7A1 Polyclonal Antibody | anti-COL7A1 antibody

COL7A1 Polyclonal Antibody

Cat. Num. AAA2524211

• Gene Names: COL7A1; EBD1; EBR1; EBDCT; NDNC8
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity purification
• Synonyms: COL7A1; Polyclonal Antibody; COL7A1 Polyclonal Antibody; EBD1; EBR1; EBDCT; anti-COL7A1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Concentration: 0.5mg/mL (varies by lot)
• Sequence Length: 2944

• Applicable Applications for anti-COL7A1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC(1:25-1:100)
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human gasrtic cancer tissue using COL7A1 Polyclonal Antibody at dilution 1:25)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using COL7A1 Polyclonal Antibody at dilution 1:25)

Related Product Information for anti-COL7A1 antibody

Background: This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen.

NCBI and Uniprot Product Information

• NCBI GI #: 4502961
• NCBI GeneID: 1294
• NCBI Accession #: NP_000085
• NCBI GenBank Nucleotide #: NM_000094.3
• UniProt Accession #: Q02388; Q14054; Q16507
• NCBI Official Full Name: collagen alpha-1(VII) chain
• NCBI Official Synonym Full Names: collagen, type VII, alpha 1
• NCBI Official Symbol: COL7A1
• NCBI Official Synonym Symbols: EBD1; EBR1; EBDCT; NDNC8
• NCBI Protein Information: collagen alpha-1(VII) chain; collagen alpha-1(VII) chain; LC collagen; collagen VII, alpha-1 polypeptide; long-chain collagen
• UniProt Protein Name: Collagen alpha-1(VII) chain
• UniProt Gene Name: COL7A1
• UniProt Synonym Gene Names: LC collagen
• UniProt Entry Name: CO7A1_HUMAN

NCBI Description

This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. [provided by RefSeq, Jul 2008]

Uniprot Description

COL7A1: the alpha chain of type VII collagen, an extra-cellular basement membrane protein restricted to the zone beneath stratified squamous epithelia. Type VII collagen fibrils are composed of three identical alpha collagen chains. Forms anchoring fibrils, which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen. Dystrophic epidermolysis bullosa can result from defects in this protein or an autoimmune response made to type VII collagen. Homotrimer. Interacts with MIA3, facilitating its loading into transport carriers and subsequent secretion. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor; Secreted; Extracellular matrix; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: extracellular matrix; extracellular space; collagen type VII; endoplasmic reticulum lumen; extracellular region; basement membrane

Molecular Function: serine-type endopeptidase inhibitor activity; identical protein binding; protein binding

Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; epidermis development; cell adhesion

Disease: Transient Bullous Dermolysis Of The Newborn; Epidermolysis Bullosa Dystrophica, Autosomal Dominant; Nail Disorder, Nonsyndromic Congenital, 8; Epidermolysis Bullosa Dystrophica, Autosomal Recessive; Epidermolysis Bullosa Dystrophica, Pretibial; Epidermolysis Bullosa Pruriginosa; Epidermolysis Bullosa With Congenital Localized Absence Of Skin And Deformity Of Nails