Rabbit anti-Human COL12 Polyclonal Antibody | anti-COL12 antibody

COL12, NT (COLEC12, CLP1, NSR2, SCARA4, SRCL, Collectin-12, Collectin placenta protein 1, Nurse cell scavenger receptor 2, Scavenger receptor class A member 4, Scavenger receptor with C-type lectin) (APC)

Cat. Num. AAA6287571

• Gene Names: COLEC12; CLP1; NSR2; SRCL; SCARA4
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: COL12; Polyclonal Antibody; NT (COLEC12; CLP1; NSR2; SCARA4; SRCL; Collectin-12; Collectin placenta protein 1; Nurse cell scavenger receptor 2; Scavenger receptor class A member 4; Scavenger receptor with C-type lectin) (APC); COLEC12; Scavenger receptor with C-type lectin; anti-COL12 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human COL12.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-COL12 antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 71-100 in the N-terminal region of human COL12, UniProt Accession #Q5KU26. Species sequence homology: bovine, rat
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in MDA-MB453 cell line lysates (35ug/lane) usingMBS646599. This demonstrates that MBS646599 detected the COL12 protein (arrow).)

Related Product Information for anti-COL12 antibody

This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that can bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. In addition, these receptors can recognize oxidized phospholipids so they may also participate in removing oxidatively damaged or apoptotic cells.

Product Categories/Family for anti-COL12 antibody

Antibodies; Receptors; Scavenger

References

1. Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010). 2. Davila, S., et al. Genes Immun. 11(3):232-238(2010). 3. Liu, Y., et al. Mol. Psychiatry (2010). In press 4. Samsen, A., et al. Eur. J. Cell Biol. 89(1):87-94(2010). 5. Jang, S., et al. J. Biol. Chem. 284(6):3956-3965(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 18641360
• NCBI GeneID: 81035
• NCBI Accession #: NP_569057.1
• NCBI GenBank Nucleotide #: NM_130386.2
• UniProt Accession #: Q5KU26; Q6P9F2; Q8TCR2; Q8WZA4; Q9BY85; Q9BYH7
• Molecular Weight: 81,515 Da
• NCBI Official Full Name: collectin-12
• NCBI Official Synonym Full Names: collectin sub-family member 12
• NCBI Official Symbol: COLEC12
• NCBI Official Synonym Symbols: CLP1; NSR2; SRCL; SCARA4
• NCBI Protein Information: collectin-12; hCL-P1; collectin placenta protein 1; nurse cell scavenger receptor 2; scavenger receptor class A, member 4; scavenger receptor with C-type lectin
• UniProt Protein Name: Collectin-12
• Protein Family: Zinc finger protein CONSTANS
• UniProt Gene Name: COLEC12
• UniProt Synonym Gene Names: CLP1; NSR2; SCARA4; SRCL; CL-P1; hCL-P1
• UniProt Entry Name: COL12_HUMAN

NCBI Description

This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, Oct 2011]