Western Blot (WB)
(Western blotAll lanes: COG4 antibody at 4.85 ug/mlLane 1: Mouse liver tissueLane 2: Mouse gonadal tissueLane 3: K562 whole cell lysateLane 4: Hela whole cell lysateSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 90,39,82 kDaObserved band size: 89 kDa)
Rabbit anti-Human, Mouse COG4 Polyclonal Antibody | anti-COG4 antibody
COG4 Antibody
Western Blot (WB)
(Western blotAll lanes: COG4 antibody at 4.85 ug/mlLane 1: Mouse liver tissueLane 2: Mouse gonadal tissueLane 3: K562 whole cell lysateLane 4: Hela whole cell lysateSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 90,39,82 kDaObserved band size: 89 kDa)
Western Blot (WB)
(Western blotAll lanes: COG4 antibody at 4.85 ug/mlLane 1: Mouse liver tissueLane 2: Mouse gonadal tissueLane 3: K562 whole cell lysateLane 4: Hela whole cell lysateSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 90,39,82 kDaObserved band size: 89 kDa)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human tonsil tissue using MBS7044569 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human tonsil tissue using MBS7044569 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7044569 at dilution 1:100)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7044569 at dilution 1:100)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
Uniprot Description
COG4: Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1. Defects in COG4 are the cause of congenital disorder of glycosylation type 2J (CDG2J). It is a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the COG4 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component: Golgi membrane; Golgi transport complex; trans-Golgi network membrane
Molecular Function: protein binding
Biological Process: ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; Golgi vesicle prefusion complex stabilization; retrograde transport, vesicle recycling within Golgi; retrograde vesicle-mediated transport, Golgi to ER
Disease: Congenital Disorder Of Glycosylation, Type Iij
Research Articles on COG4
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Product Notes
The COG4 cog4 (Catalog #AAA7044569) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The COG4 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's COG4 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the COG4 cog4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COG4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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