Western Blot (WB)
(Western Blot (WB) analysis of COG2 polyclonal antibody)
Rabbit COG2 Polyclonal Antibody | anti-COG2 antibody
COG2 Polyclonal Antibody
Gene Names
COG2; LDLC; CDG2Q
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
COG2; Polyclonal Antibody; COG2 Polyclonal Antibody; Brefeldin A sensitive peripheral Golgi protein; COG 2; COG complex subunit 2; COG2_HUMAN; Component of oligomeric golgi complex 2; Conserved oligomeric Golgi complex component 2; Conserved oligomeric Golgi complex subunit 2; LDLC; Low density lipoprotein receptor defect C complementing protein; Low density lipoprotein receptor defect C-complementing protein; Transcript ch4822; anti-COG2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
COG2 polyclonal antibody detects endogenous levels of COG2 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
737
Applicable Applications for anti-COG2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
WB: 1:500-1:2000
IHC: 1:50-1:200
IHC: 1:50-1:200
Immunogen
Recombinant full length Human COG2.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Western Blot (WB)
(Western Blot (WB) analysis of COG2 polyclonal antibody)
Western Blot (WB)
(Western Blot (WB) analysis of COG2 polyclonal antibody)
Related Product Information for anti-COG2 antibody
The structure and function of the Golgi apparatus is controlled by a number of multi-protein complexes that are involved in glycosylation reactions and vesicular transport. The conserved oligomeric Golgi (COG) complex consists of three subcomplexes, termed LDLC, SEC34 and GTT (Golgi transport complex), all of which contain proteins necessary for proper Golgi operation. COG2 (conserved oligomeric Golgi complex subunit 2), also known as LDLC, is a 730 amino acid component of the COG complex. Localized to the cytoplasmic side of the Golgi apparatus, COG2 is required for proper Golgi morphology and function, specifically playing a role in Golgi ribbon formation and vesicular transport. Abnormal COG2 function may cause cell death, suggesting that COG2 is an important factor in cell viability.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 83kDa
NCBI Official Full Name
conserved oligomeric Golgi complex subunit 2 isoform 2
NCBI Official Synonym Full Names
component of oligomeric golgi complex 2
NCBI Official Symbol
COG2
NCBI Official Synonym Symbols
LDLC; CDG2Q
NCBI Protein Information
conserved oligomeric Golgi complex subunit 2
UniProt Protein Name
Conserved oligomeric Golgi complex subunit 2
Protein Family
UniProt Gene Name
COG2
UniProt Synonym Gene Names
LDLC; COG complex subunit 2
UniProt Entry Name
COG2_HUMAN
NCBI Description
This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]
Uniprot Description
COG2: Required for normal Golgi morphology and function. Belongs to the COG2 family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 1q42.2
Cellular Component: Golgi membrane; Golgi stack; Golgi transport complex; cytosol
Molecular Function: protein binding; protein complex binding; protein transporter activity
Biological Process: intracellular protein transport; intra-Golgi vesicle-mediated transport; oligosaccharide biosynthetic process; protein amino acid glycosylation; Golgi organization and biogenesis
Research Articles on COG2
1. Our data strongly suggest that these compound heterozygous mutations in COG2 are causative of CDG.
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Product Notes
The COG2 cog2 (Catalog #AAA3011420) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The COG2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's COG2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). WB: 1:500-1:2000 IHC: 1:50-1:200. Researchers should empirically determine the suitability of the COG2 cog2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COG2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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