Western Blot (WB)
(COCH Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the COCH antibody detected the COCH protein (arrow).)
Rabbit COCH Polyclonal Antibody | anti-COCH antibody
COCH Antibody (C-term)
Western Blot (WB)
(COCH Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the COCH antibody detected the COCH protein (arrow).)
Western Blot (WB)
(COCH Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the COCH antibody detected the COCH protein (arrow).)
Western Blot (WB)
(Western blot analysis of COCH (arrow) using rabbit polyclonal COCH Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the COCH gene.)
Western Blot (WB)
(Western blot analysis of COCH (arrow) using rabbit polyclonal COCH Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the COCH gene.)
human, mouse, and chicken, showing 94% and 79% amino acid identity
of human to mouse and chicken sequences, respectively.
Hybridization to this gene was detected in spindle-shaped cells
located along nerve fibers between the auditory ganglion and
sensory epithelium. These cells accompany neurites at the habenula
perforata, the opening through which neurites extend to innervate
hair cells. This and the pattern of expression of this gene in
chicken inner ear paralleled the histologic findings of acidophilic
deposits, consistent with mucopolysaccharide ground substance, in
temporal bones from DFNA9 (autosomal dominant nonsyndromic
sensorineural deafness 9) patients. Mutations that cause DFNA9 have
been reported in this gene. Alternative splicing results in
multiple transcript variants encoding the same protein. Additional
splice variants encoding distinct isoforms have been described but
their biological validities have not been demonstrated. [provided
by RefSeq].
Yao, J., et al. J. Biol. Chem. 285(20):14909-14919(2010)
Baek, J.I., et al. Clin. Genet. 77(4):399-403(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Lee, E.S., et al. Invest. Ophthalmol. Vis. Sci. 51(4):2060-2066(2010)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq, Oct 2008]
Uniprot Description
COCH: Plays a role in the control of cell shape and motility in the trabecular meshwork. Defects in COCH are the cause of deafness autosomal dominant type 9 (DFNA9). DFNA9 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA9 is characterized by onset in the fourth or fifth decade of life and initially involves the high frequencies. Deafness is progressive and usually complete by the sixth decade. In addition to cochlear involvement, DFNA9 patients also exhibit a spectrum of vestibular dysfunctions. Penetrance of the vestibular symptoms is often incomplete, and some patients are minimally affected, whereas others suffer from severe balance disturbances and episodes of vertigo. Affected individuals have mucopolysaccharide depositions in the channels of the cochlear and vestibular nerves. These depositions apparently cause strangulation and degeneration of dendritic fibers.
Protein type: Extracellular matrix; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 14q11.2-q13
Cellular Component: extracellular matrix; proteinaceous extracellular matrix
Molecular Function: collagen binding; protein binding
Biological Process: regulation of cell shape; sensory perception of sound; defense response to bacterium; positive regulation of innate immune response
Disease: Deafness, Autosomal Dominant 9
Research Articles on COCH
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Product Notes
The COCH coch (Catalog #AAA9209681) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 492-520. The COCH Antibody (C-term) reacts with Human (Predicted Reactivity: Bovine) and may cross-react with other species as described in the data sheet. AAA Biotech's COCH can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the COCH coch for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "COCH, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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