Western Blot (WB)
(Western blot analysis of CNTNAP2 Antibody (Center) in CEM cell line lysates (35ug/lane). CNTNAP2 (arrow) was detected using the purified Pab.)
Rabbit anti-Human CNTNAP2 Polyclonal Antibody | anti-CNTNAP2 antibody
CNTNAP2 Antibody (Center)
Western Blot (WB)
(Western blot analysis of CNTNAP2 Antibody (Center) in CEM cell line lysates (35ug/lane). CNTNAP2 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of CNTNAP2 Antibody (Center) in CEM cell line lysates (35ug/lane). CNTNAP2 (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded mouse brain tissue reacted with CNTNAP2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(Formalin-fixed and paraffin-embedded mouse brain tissue reacted with CNTNAP2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.)
Nakayama,M., et.al., Genome Res. 12 (11), 1773-1784 (2002)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.[provided by RefSeq, Mar 2010]
Uniprot Description
CNTNAP2: May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction. Associates with KCNA2. Predominantly expressed in nervous system. Belongs to the neurexin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q35
Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; cell surface; membrane; cell soma; axon; early endosome; dendrite; integral to membrane; perikaryon; axolemma
Molecular Function: enzyme binding
Biological Process: striatum development; limbic system development; neuron recognition; transmission of nerve impulse; learning; thalamus development; social behavior; adult behavior; clustering of voltage-gated potassium channels; cerebral cortex development; brain development; cell adhesion; neurite development
Disease: Autism, Susceptibility To, 15; Cortical Dysplasia-focal Epilepsy Syndrome
Research Articles on CNTNAP2
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Product Notes
The CNTNAP2 cntnap2 (Catalog #AAA9206640) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1079-1106. The CNTNAP2 Antibody (Center) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CNTNAP2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the CNTNAP2 cntnap2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CNTNAP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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