Immunohistochemistry (IHC)
(Anti-CNTN1 / gp135 / Contactin 1 antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Goat CNTN1 / gp135 / Contactin 1 Polyclonal Antibody | anti-CNTN1 antibody
Goat Polyclonal to Human CNTN1 / gp135 / Contactin 1
Usage: Peptide ELISA: antibody detection limit dilution 1:32000. Western blot: Approx 140kD band observed in Human, Mouse and Rat Brain lysates (calculated MW of 113kD according to NP_001834.2). The observed molecular weight corresponds to the glycosylated...
Immunohistochemistry (IHC)
(Anti-CNTN1 / gp135 / Contactin 1 antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Immunohistochemistry (IHC)
(Anti-CNTN1 / gp135 / Contactin 1 antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Western Blot (WB)
(CNTN1 antibody (0.3 ug/ml) staining of Human Cerebellum (A), Mouse Brain (B) and Rat Brain (C) lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
Western Blot (WB)
(CNTN1 antibody (0.3 ug/ml) staining of Human Cerebellum (A), Mouse Brain (B) and Rat Brain (C) lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
CNTN1: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth. Defects in CNTN1 are the cause of Compton-North congenital myopathy (CNCM). CNCM is a familial lethal form of congenital onset muscle weakness, inherited in an autosomal-recessive fashion and characterized by a secondary loss of beta2-syntrophin and alpha-dystrobrevin from the muscle sarcolemma, central nervous system involvement, and fetal akinesia. Belongs to the immunoglobulin superfamily. Contactin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Membrane protein, GPI anchor
Chromosomal Location of Human Ortholog: 12q11-q12
Cellular Component: membrane; plasma membrane
Molecular Function: carbohydrate binding; glycoprotein binding
Biological Process: axon guidance; Notch signaling pathway; cerebellum development; cell adhesion
Disease: Myopathy, Congenital, Compton-north
Research Articles on CNTN1
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Product Notes
The CNTN1 cntn1 (Catalog #AAA248030) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat Polyclonal to Human CNTN1 / gp135 / Contactin 1 reacts with Gibbon, Chimpanzee, Guinea pig, Human, Monkey, Mouse, Pig, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CNTN1 / gp135 / Contactin 1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA). ELISA (1:32000), IHC-P (5 ug/ml), WB (0.3 - 1 ug/ml) Usage: Peptide ELISA: antibody detection limit dilution 1:32000. Western blot: Approx 140kD band observed in Human, Mouse and Rat Brain lysates (calculated MW of 113kD according to NP_001834.2). The observed molecular weight corresponds to the glycosylated.. Researchers should empirically determine the suitability of the CNTN1 cntn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CNTN1 / gp135 / Contactin 1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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