Rabbit CNTFR Polyclonal Antibody | anti-CNTFR antibody

Anti-CNTFR Antibody

Cat. Num. AAA416347

• Reactivity: Human. Not yet tested in other species
• Applications: ELISA, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: CNTFR; Polyclonal Antibody; Anti-CNTFR Antibody; anti-CNTFR antibody

• Host: Rabbit
• Reactivity: Human. Not yet tested in other species
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 372

• Applicable Applications for anti-CNTFR antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Peptide ELISA titer: 1:8,000-1:30,000; Western blot analysis: 1:50-200; Optimal dilutions/concentrations should be determined by the end user
• Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide
• Immunogen: Rabbit polyclonal CNTFR antibody was raised against a 14 amino acid peptide from the internal residues of human CNTFR
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Immunohistochemistry (IHC)

Related Product Information for anti-CNTFR antibody

This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

References

(1) Rousseau,F., Gauchat,J.F., McLeod,J.G¯Å'et,al Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient. PNAS.2008;105 (35):10068-10073.

NCBI and Uniprot Product Information

• NCBI GI #: 333108228
• NCBI GeneID: 1271
• NCBI Accession #: NP_001193940.1
• NCBI GenBank Nucleotide #: NM_001207011.1
• Molecular Weight: 40,633 Da
• NCBI Official Full Name: ciliary neurotrophic factor receptor subunit alpha preproprotein
• NCBI Official Synonym Full Names: ciliary neurotrophic factor receptor
• NCBI Official Symbol: CNTFR
• NCBI Protein Information: ciliary neurotrophic factor receptor subunit alpha; CNTF receptor subunit alpha; CNTFR-alpha
• UniProt Protein Name: Ciliary neurotrophic factor receptor subunit alpha
• Protein Family: Ciliary neurotrophic factor receptor
• UniProt Gene Name: CNTFR
• UniProt Entry Name: CNTFR_HUMAN

NCBI Description

This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

Uniprot Description

CNTFR: Binds to CNTF. The alpha subunit provides the receptor specificity. Belongs to the type I cytokine receptor family. Type 3 subfamily.

Protein type: Membrane protein, GPI anchor; Receptor, misc.

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extrinsic to membrane

Molecular Function: cytokine binding; ciliary neurotrophic factor receptor activity; receptor binding

Biological Process: nervous system development; suckling behavior; positive regulation of cell proliferation; negative regulation of neuron apoptosis; signal transduction; sex differentiation