Rabbit CNR1 / CB1 Polyclonal Antibody | anti-CNR1 antibody

Rabbit Polyclonal to Human CNR1 / CB1

Cat. Num. AAA244389

• Gene Names: CNR1; CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5
• Reactivity: Chimpanzee, Hamster, Human, Monkey, Mouse, Rat
• Applications: Immunohistochemistry, Immunocytochemistry
• Purity: Immunoaffinity Purified
• Synonyms: CNR1 / CB1; Polyclonal Antibody; Rabbit Polyclonal to Human CNR1 / CB1; Anti-CNR1 / CB1 Antibody (Cytoplasmic Domain) IHC-plus; CNR1; CB-R; CB1 receptor; CB1A; CB1R; Cannabinoid receptor 1; Cannabinoid receptor CB1; Cannabinoid Receptor I; CB1; CB1K5; CANN6; Cannabinoid receptor 1 (brain); CNR; Cannabinoid CB(1) receptor; CB1 cannabinoid receptor; Central cannabinoid receptor; Human CNR1; anti-CNR1 antibody

• Host: Rabbit
• Reactivity: Chimpanzee, Hamster, Human, Monkey, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Human CNR1 / CB1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 472

• Applicable Applications for anti-CNR1 antibody: Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC)
• Application Notes: ICC, IHC-P (8 - 11 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human CNR1 / CB1. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Monkey, Mouse, Rat, Shrew, Hamster, Elephant, Cat (100%).
• Immunogen Type: Synthetic peptide
• Immunogen: CNR1 / CB1 antibody was raised against synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human CNR1 / CB1. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Monkey, Mouse, Rat, Shrew, Hamster, Elephant, Cat (100%).
• Antigen Modification: Cytoplasmic Domain
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-CNR1 / CB1 antibody IHC of human brain, neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-CNR1 / CB1 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Transfection

(Anti-CNR1 / CB1 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with CNR1 / CB1.)

Transfection Control

(Anti-CNR1 / CB1 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.)

Related Product Information for anti-CNR1 antibody

CB1 Cannabinoid receptor is associated with the regulation of cognition, memory, and motor activity. The CB1 receptor mediates cannabinoid-induced CNS effects and the addictive behavior experienced by users of marijuana. Three splice variants that are produced by alternative splicing have been identified for this gene.

Product Categories/Family for anti-CNR1 antibody

Family: GPCR; Subfamily: Cannabinoid

NCBI and Uniprot Product Information

• NCBI GI #: 237681067
• NCBI GeneID: 1268
• NCBI Accession #: NP_001153698.1
• NCBI GenBank Nucleotide #: NM_001160226.1
• UniProt Accession #: P21554; Q13949; Q495Z0; Q4PLI4; Q4VBM6; Q5JVL5; Q5UB37; Q9UNN0; B2R9T4; E1P512
• Molecular Weight: 49,060 Da
• NCBI Official Full Name: cannabinoid receptor 1 isoform a
• NCBI Official Synonym Full Names: cannabinoid receptor 1 (brain)
• NCBI Official Symbol: CNR1
• NCBI Official Synonym Symbols: CB1; CNR; CB-R; CB1A; CB1R; CANN6; CB1K5
• NCBI Protein Information: cannabinoid receptor 1; central cannabinoid receptor
• UniProt Protein Name: Cannabinoid receptor 1
• Protein Family: Cannabinoid receptor
• UniProt Gene Name: CNR1
• UniProt Synonym Gene Names: CNR; CB-R; CB1
• UniProt Entry Name: CNR1_HUMAN

NCBI Description

This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]

Uniprot Description

CNR1: Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6q14-q15

Cellular Component: growth cone; intracellular membrane-bound organelle; axon; integral to plasma membrane; plasma membrane

Molecular Function: cannabinoid receptor activity; drug binding

Biological Process: response to nicotine; negative regulation of fatty acid beta-oxidation; maternal process involved in pregnancy; regulation of synaptic transmission, glutamatergic; positive regulation of apoptosis; positive regulation of acute inflammatory response to antigenic stimulus; response to morphine; response to lipopolysaccharide; sensory perception of pain; glucose homeostasis; negative regulation of blood pressure; negative regulation of dopamine secretion; response to nutrient; aging; negative regulation of mast cell activation; negative regulation of nitric-oxide synthase activity; axonal fasciculation; negative regulation of action potential; response to cocaine; memory; regulation of synaptic transmission, GABAergic; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to cyclic nucleotide second messenger; response to ethanol; positive regulation of fever; spermatogenesis; regulation of insulin secretion; positive regulation of blood pressure