Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 46948(CELA3A Antibody) at dilution 1/25. (Original magnification: 200))
Rabbit anti-Human CNOT10 Polyclonal Antibody | anti-CNOT10 antibody
CNOT10 Antibody
Reactivity
Human
Applications
Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
CNOT10; Polyclonal Antibody; CNOT10 Antibody; anti-CNOT10 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
The antibody detects endogenous levels of total CNOT10 protein.
Purity/Purification
Antigen affinity purification
Form/Format
In pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Concentration
0.9mg/ml (varies by lot)
Sequence Length
2578
Applicable Applications for anti-CNOT10 antibody
Immunohistochemistry (IHC)
Application Notes
IF: 1: 20-100
Immunogen
Fusion protein of human CNOT10
Immunogen Type
Protein
Preparation and Storage
Store at -20 degree C.
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 46948(CELA3A Antibody) at dilution 1/25. (Original magnification: 200))
Immunohistochemistry (IHC)
(The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using 46948(CELA3A Antibody) at dilution 1/25. (Original magnification: 200))
Related Product Information for anti-CNOT10 antibody
CNOT10 is a subunit of the CCR4-NOT complex which consists of at least five other CNOT subunit proteins and TAB182. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription, as well as in mRNA degradation. Various subunits (e.g. CNOT1, CNOT3) are uniquely involved in influencing nuclear hormone receptor activities. In effect, this complex has an important role as a transcription regulator and repressor of nuclear receptor signaling that is relevant to the molecular pathways involved in cancer. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome.
Product Categories/Family for anti-CNOT10 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
89,141 Da
NCBI Official Full Name
Homo sapiens CCR4-NOT transcription complex, subunit 10, mRNA
NCBI Official Synonym Full Names
CCR4-NOT transcription complex subunit 10
NCBI Official Symbol
CNOT10
NCBI Protein Information
CCR4-NOT transcription complex subunit 10
UniProt Protein Name
CCR4-NOT transcription complex subunit 10
Protein Family
UniProt Gene Name
CNOT10
Uniprot Description
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex.
Research Articles on CNOT10
Similar Products
Product Notes
The CNOT10 cnot10 (Catalog #AAA9429911) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CNOT10 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CNOT10 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). IF: 1: 20-100. Researchers should empirically determine the suitability of the CNOT10 cnot10 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CNOT10, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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