Rabbit anti-Human CNNM2 Polyclonal Antibody | anti-CNNM2 antibody

CNNM2, CT (CNNM2, ACDP2, Metal transporter CNNM2, Ancient conserved domain-containing protein 2, Cyclin-M2) (AP)

Cat. Num. AAA6287218

• Gene Names: CNNM2; ACDP2; HOMG6; HOMGSMR
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CNNM2; Polyclonal Antibody; CT (CNNM2; ACDP2; Metal transporter CNNM2; Ancient conserved domain-containing protein 2; Cyclin-M2) (AP); Cyclin-M2; anti-CNNM2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
• Sequence Length: 853

• Applicable Applications for anti-CNNM2 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: CNNM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 645-674 amino acids from the C-terminal region of human CNNM2.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(CNNM2 Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the CNNM2 antibody detected the CNNM2 protein (arrow).)

Related Product Information for anti-CNNM2 antibody

CNNM2 is a divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+) (By similarity).

Product Categories/Family for anti-CNNM2 antibody

Antibodies; Cyclin

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Takeuchi, F., et al. Circulation 121(21):2302-2309(2010). Yasuno, K., et al. Nat. Genet. 42(5):420-425(2010). Simon-Sanchez, J., et al. Nat. Genet. 41(12):1308-1312(2009). Newton-Cheh, C., et al. Nat. Genet. 41(6):666-676(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 40068055
• NCBI GeneID: 54805
• NCBI Accession #: NP_951058.1; NP_060119.3
• NCBI GenBank Nucleotide #: NP_951058.1
• UniProt Accession #: Q9H8M5
• NCBI Official Full Name: metal transporter CNNM2 isoform 2
• NCBI Official Synonym Full Names: cyclin and CBS domain divalent metal cation transport mediator 2
• NCBI Official Symbol: CNNM2
• NCBI Official Synonym Symbols: ACDP2; HOMG6; HOMGSMR
• NCBI Protein Information: metal transporter CNNM2
• UniProt Protein Name: Metal transporter CNNM2
• Protein Family: Metal transporter
• UniProt Gene Name: CNNM2
• UniProt Synonym Gene Names: ACDP2
• UniProt Entry Name: CNNM2_HUMAN

NCBI Description

This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play an important role in magnesium homeostasis by mediating the epithelial transport and renal reabsorption of Mg2+. Mutations in this gene are associated with renal hypomagnesemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

CNNM2: Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+). Defects in CNNM2 are the cause of hypomagnesemia type 6 (HOMG6). A renal disease characterized by severely lowered serum magnesium levels in the absence of other electrolyte disturbances. Affected individuals show an inappropriately normal urinary magnesium excretion, demonstrating a defect in tubular reabsorption. Age of clinical onset is highly variable and some affected individuals are asymptomatic. Belongs to the ACDP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Cell cycle regulation; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q24.32

Cellular Component: basolateral plasma membrane; integral to membrane

Biological Process: magnesium ion transport

Disease: Hypomagnesemia, Seizures, And Mental Retardation; Hypomagnesemia 6, Renal