Rabbit anti-Rat CNG4 Polyclonal Antibody | anti-CNGB1 antibody

CNG4 (Cyclic Nucleotide-Gated Channels 4, b-Subunit)

Cat. Num. AAA614865

• Gene Names: CNGB1; CNG4; GAR1; GARP; RP45; CNCG2; CNCG4; RCNC2; RCNCb; CNCG3L; CNGB1B; RCNCbeta
• Reactivity: Rat
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: CNG4; Polyclonal Antibody; CNG4 (Cyclic Nucleotide-Gated Channels 4; b-Subunit); Anti -CNG4 (Cyclic Nucleotide-Gated Channels 4; anti-CNGB1 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes rat CNG4. No significant sequence homology is detected with other CNGs.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4 0.1% BSA.

• Applicable Applications for anti-CNGB1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Immunogen: A 24aa synthetic peptide sequence near C-terminus of rat CNG4. (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-CNGB1 antibody

The cyclic nucleotides cAMP and cGMP are implicated in signal transduction events such as the visual transduction, relaxation of smooth muscles, intestinal secretion of water and salt, reabsorption of Na+ and water in the distal tubule of the nephrons. cAMP/cGMP activate Ca2+ -permeable ion channels called cyclic nucleotide-gated channels (CNG or CNC). Activation of CNG leads to depolarization of the membrane voltage and to a concomitant increase of the cytosolic Ca2+. CNG consists of two distinct subunits, designated a and b subunits. Several CNG a-subunits (CNG alpha 1-3) & beta subunits (subunit 2 or CNGb1-2 or CNG4-5) and numerous isoforms. a-subunit can form functional channel by themselves, whereas, b-subunits modulate the channel property of a-subunits. CNG display intracellular N and C-termini, 6 transmembrane domains or segments (S1-S6). The region between S5 and S6 contains the ion-conducting pore (P). The cyclic nucleotide-binding region is found at the c-terminus. Native functional CNG may exists as heteromultimer containing some combination of a, and b subunits. CNG beta-subunit or subunit 2 (also called CNG4) have been cloned from the rod outer segments (hRCNC2a and hRCNC2b) and from olfactory neurons (rOCNC2, also called CNG5). Human RCNC2a (623 aa; missing 1-286 aa) and RCNC2b (909 aa) are alternatively splice and only differ in their N-terminus. The two b proteins show ~30% identity with human a CNG1. Additional alternatively spliced CNG4D (missing 522-530 aa) and CNG4E (missing 515-532 aa) are also expressed. CNG b-subunits form heterooligomeric complex with CNG1-3. The olfactory b-subunit is expressed throughout the nasal epithelium, especially in olfactory sensory neurons, and in the vomeronasal organ.

Product Categories/Family for anti-CNGB1 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 208431781
• NCBI GeneID: 1258
• NCBI Accession #: NP_001129111.1
• NCBI GenBank Nucleotide #: NM_001135639.1
• UniProt Accession #: Q14028; O43636; Q13059; Q14029; Q9UMG2; AAB32607
• Molecular Weight: 139,678 Da
• NCBI Official Full Name: cyclic nucleotide-gated cation channel beta-1 isoform b
• NCBI Official Synonym Full Names: cyclic nucleotide gated channel beta 1
• NCBI Official Symbol: CNGB1
• NCBI Official Synonym Symbols: CNG4; GAR1; GARP; RP45; CNCG2; CNCG4; RCNC2; RCNCb; CNCG3L; CNGB1B; RCNCbeta
• NCBI Protein Information: cyclic nucleotide-gated cation channel beta-1; CNG-4; CNG channel beta-1; glutamic acid-rich protein; glutamic-acid-rich protein; cyclic nucleotide-gated channel beta-1; cyclic nucleotide-gated cation channel 4; cyclic nucleotide-gated cation channel gamma; cyclic nucleotide-gated cation channel modulatory subunit
• UniProt Protein Name: Cyclic nucleotide-gated cation channel beta-1
• Protein Family: Cyclic nucleotide-gated cation channel
• UniProt Gene Name: CNGB1
• UniProt Synonym Gene Names: CNCG2; CNCG3L; CNCG4; RCNC2; CNG channel 4; CNG-4; CNG4; CNG channel beta-1; GARP
• UniProt Entry Name: CNGB1_HUMAN

NCBI Description

In humans, the rod photoreceptor cGMP-gated cation channel helps regulate ion flow into the rod photoreceptor outer segment in response to light-induced alteration of the levels of intracellular cGMP. This channel consists of two subunits, alpha and beta, with the protein encoded by this gene representing the beta subunit. Defects in this gene are a cause of cause of retinitis pigmentosa type 45. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Uniprot Description

CNGB1: an integral membrane protein that forms a heterooligomeric complex with CNGA1. A modulatory subunit of cyclic nucleotide-gated cation channels.

Protein type: Membrane protein, integral; Channel, cation; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: Golgi membrane; integral to plasma membrane; plasma membrane; intracellular cyclic nucleotide activated cation channel complex; terminal button

Molecular Function: voltage-gated potassium channel activity; protein binding; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; cGMP binding; cAMP binding; ligand-gated ion channel activity

Biological Process: phototransduction, visible light; cytosolic calcium ion homeostasis; organelle organization and biogenesis; photoreceptor cell maintenance; sensory perception of smell; rhodopsin mediated signaling; retinal homeostasis; regulation of membrane potential; regulation of rhodopsin mediated signaling; visual perception; transport; protein localization in organelle; protein heterotetramerization; detection of light stimulus involved in visual perception; cation transport

Disease: Retinitis Pigmentosa 45