Rabbit anti-Rat CNG2 Polyclonal Antibody | anti-CNGA2 antibody
CNG2 (Cyclic Nucleotide-Gated Channels 2)
Gene Names
CNGA2; CNCA; CNG2; CNCA1; OCNC1; OCNCa; OCNCALPHA
Reactivity
Rat
Applications
ELISA, Western Blot
Purity
SerumSerum
Synonyms
CNG2; Polyclonal Antibody; CNG2 (Cyclic Nucleotide-Gated Channels 2); Anti -CNG2 (Cyclic Nucleotide-Gated Channels 2); anti-CNGA2 antibody
Host
Rabbit
Reactivity
Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes rat CNG2. No significant sequence homology is detected with other CNGs.
Purity/Purification
Serum
Serum
Serum
Form/Format
Supplied as a liquid in PBS, 0.05% sodium azide.
Applicable Applications for anti-CNGA2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000-1:5000 (ECL).
ELISA: 1:10,000-1:50,000. Coat ELISA plates at 1ug/ml with Control Peptide.
Dilution: Western Blot: 1:1000-1:5000 (ECL).
ELISA: 1:10,000-1:50,000. Coat ELISA plates at 1ug/ml with Control Peptide.
Immunogen
Synthetic peptide corresponding to 18aa sequence near the N-terminus of rat/mouse CNG2 (KLH). Species sequence homology: mouse (100%); bovine and rabbit: (94%).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-CNGA2 antibody
The cyclic nucleotides cAMP and cGMP are implicated in signal transduction events such as the visual transduction, relaxation of smooth muscles, intestinal secretion of water and salt, reabsorption of Na+ and water in the distal tubule of the nephrons. cAMP/cGMP activate Ca2+ -permeable ion channels called cyclic nucleotide-gated channels (CNG or CNC). Activation of CNG leads to depolarization of the membrane voltage and to a concomitant increase of the cytosolic Ca2+. CNG consists of two distinct subunits, designated a and b subunits. Several CNG a-subunits (CNG alpha 1-3) & beta subunits (subunit 2 or CNGb1-2 or CNG4-5) and numerous isoforms. a-subunit can form functional channel by themselves. b-subunits modulate the channel property of a-subunits. CNG display intracellular N and C-termini, 6 transmembrane domains or segments (S1-S6). The region between S5 and S6 contains the ion-conducting pore (P). The cyclic nucleotide-binding region is found at the c-terminus. Native functional CNG may exists as heteromultimer containing some combination of a, and b subunits. CNG2 or OCNC1 (rat/mouse/rabbit 664 aa, bovine 663 aa) is primarily expressed in olfactory sensory neurons. It is ~80% homologous with CNG1. Unlike CNG1, CNG2 is activated both by cAMP and cGMP. Another cGMP-gated channel called CNG3 (mouse 537aa, rat 61 aa, human, 694aa, bovine 706aa, chicken 64 aa) has been cloned from heart, kidney, testis, sperm, and taste buds.
Product Categories/Family for anti-CNGA2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
76,048 Da
NCBI Official Full Name
cyclic nucleotide-gated olfactory channel
NCBI Official Synonym Full Names
cyclic nucleotide gated channel alpha 2
NCBI Official Symbol
CNGA2
NCBI Official Synonym Symbols
CNCA; CNG2; CNCA1; OCNC1; OCNCa; OCNCALPHA
NCBI Protein Information
cyclic nucleotide-gated olfactory channel; CNG-2; CNG channel alpha-2; cyclic nucleotide-gated channel alpha-2; cyclic nucleotide-gated cation channel 2; cyclic-nucleotide-gated cation channel 2; cyclic-nucleotide-gated olfactory channel
UniProt Protein Name
Cyclic nucleotide-gated olfactory channel
Protein Family
UniProt Gene Name
CNGA2
UniProt Synonym Gene Names
CNCA; CNCA1; CNCG2; CNG channel alpha-2; CNG-2; CNG2
UniProt Entry Name
CNGA2_HUMAN
NCBI Description
The protein encoded by this gene represents the alpha subunit of a cyclic nucleotide-gated olfactory channel. The encoded protein contains a carboxy-terminal leucine zipper that mediates channel formation. [provided by RefSeq, Jan 2010]
Uniprot Description
CNGA2: Odorant signal transduction is probably mediated by a G- protein coupled cascade using cAMP as second messenger. The olfactory channel can be shown to be activated by cyclic nucleotides which leads to a depolarization of olfactory sensory neurons. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: Xq27
Cellular Component: Golgi membrane; integral to plasma membrane
Molecular Function: calmodulin binding; voltage-gated potassium channel activity; intracellular cGMP activated cation channel activity; cGMP binding; cAMP binding
Biological Process: phototransduction, visible light; regulation of membrane potential; organelle organization and biogenesis; sensory perception of smell
Research Articles on CNGA2
Similar Products
Product Notes
The CNGA2 cnga2 (Catalog #AAA611339) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CNG2 (Cyclic Nucleotide-Gated Channels 2) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CNG2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: Western Blot: 1:1000-1:5000 (ECL). ELISA: 1:10,000-1:50,000. Coat ELISA plates at 1ug/ml with Control Peptide. Researchers should empirically determine the suitability of the CNGA2 cnga2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CNG2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
