Rabbit anti-Human, Mouse CMYA5 Polyclonal Antibody | anti-CMYA5 antibody
CMYA5 Antibody
Gene Names
CMYA5; SPRYD2; TRIM76; C5orf10
Reactivity
Human, Mouse
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
CMYA5; Polyclonal Antibody; CMYA5 Antibody; 2310076E16Rik; C5orf10; Cardiomyopathy associated 5; Cardiomyopathy associated protein 5; Cardiomyopathy-associated protein 5; Chromosome 5 open reading frame 10; CMYA 5; Cmya5; CMYA5_HUMAN; DKFZp451G182; DKFZp451G223; DTNBP2; Dystrobrevin binding protein 2; Dystrobrevin-binding protein 2; Genethonin 3; Genethonin-3; Myospryn; SPRY domain containing protein 2; SPRY domain-containing protein 2; SPRYD2; TRIM76; Tripartite motif containing 76; Tripartite motif containing protein 76; Tripartite motif-containing protein 76; anti-CMYA5 antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
CMYA5 Antibody detects endogenous levels of CMYA5.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-CMYA5 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human CMYA5.
Conjugation
Unconjugated
Similarity
Amphipathic helix regions act as an anchoring domain for PKA, and appear to be responsible of the interaction between myospryn and PRKAR2A.
Post Translational Modifications
Phosphorylated by PKA.
Subunit Structure
Interacts with PRKAR2A. Interacts with ACTN2 and DTNBP1/dysbindin (By similarity). Interacts with DES. Interacts with DMD/dystrophin (By similarity). Interacts with the calcineurin catalytic subunit PPP3CA (By similarity). Interacts with TTN. Interacts with CAPN3; this interaction, which results in CMYA5 proteolysis, may protect CAPN3 from autolysis. Interacts with FSD2 (By similarity). Identified in a complex composed of FSD2, CMYA5 and RYR2 (By similarity).
Tissue Specificity
Expressed in skeletal muscle; at a strong level and in heart.
Function
May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A (By similarity). May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration (By similarity). Plays a role in the assembly of ryanodine receptor (RYR2) clusters in striated muscle (By similarity).
Note
Found predominantly at the periphery of the nucleus but also throughout the cell. Localized in lysosomes (By similarity). In skeletal muscles, localizes along myofiber periphery, at costameres (By similarity). Predominantly flanks Z-disks (By similarity). Occasionally present at the M-band level. Colocalized with RYR2 in the sarcoplasmic reticulum (By similarity).
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-CMYA5 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
449,211 Da
NCBI Official Full Name
cardiomyopathy-associated protein 5
NCBI Official Synonym Full Names
cardiomyopathy associated 5
NCBI Official Symbol
CMYA5
NCBI Official Synonym Symbols
SPRYD2; TRIM76; C5orf10
NCBI Protein Information
cardiomyopathy-associated protein 5; myospryn; genethonin-3; 2310076E16Rik; dystrobrevin-binding protein 2; tripartite motif-containing 76; SPRY domain-containing protein 2; tripartite motif-containing protein 76
UniProt Protein Name
Cardiomyopathy-associated protein 5
Protein Family
UniProt Gene Name
CMYA5
UniProt Synonym Gene Names
C5orf10; DTNBP2; SPRYD2; TRIM76
UniProt Entry Name
CMYA5_HUMAN
Uniprot Description
CMYA5: May serve as an anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) via binding to PRKAR2A. May function as a repressor of calcineurin-mediated transcriptional activity. May attenuate calcineurin ability to induce slow-fiber gene program in muscle and may negatively modulate skeletal muscle regeneration.
Chromosomal Location of Human Ortholog: 5q14.1
Cellular Component: costamere; perinuclear region of cytoplasm; M band
Molecular Function: identical protein binding; protein binding
Biological Process: negative regulation of protein phosphatase type 2B activity; regulation of skeletal muscle adaptation
Research Articles on CMYA5
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Product Notes
The CMYA5 cmya5 (Catalog #AAA9629963) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CMYA5 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CMYA5 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the CMYA5 cmya5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CMYA5, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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