Western Blot (WB)
(Western Blot analysis of CMPK expression in transfected 293T cell line by CMPK polyclonal antibody. Lane 1: CMPK transfected lysate (26kD). Lane 2: Non-transfected lysate.)
Rabbit anti-Human CMPK1 Polyclonal Antibody | anti-cmpk1 antibody
CMPK1 (UMP-CMP Kinase, Deoxycytidylate Kinase, CK, dCMP Kinase, Uridine Monophosphate/Cytidine Monophosphate Kinase, UMP/CMP Kinase, UMP/CMPK, CMK, CMPK, UCK, UMK, UMPK)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot analysis of CMPK expression in transfected 293T cell line by CMPK polyclonal antibody. Lane 1: CMPK transfected lysate (26kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of CMPK expression in transfected 293T cell line by CMPK polyclonal antibody. Lane 1: CMPK transfected lysate (26kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
Uniprot Description
Function: Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity
By similarity. HAMAP-Rule MF_03172
Catalytic activity: ATP + (d)CMP = ADP + (d)CDP. HAMAP-Rule MF_03172ATP + UMP = ADP + UDP. HAMAP-Rule MF_03172ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. HAMAP-Rule MF_03172
Cofactor: Binds 1 magnesium ion per monomer
By similarity. HAMAP-Rule MF_03172
Subunit structure: Monomer
By similarity. HAMAP-Rule MF_03172
Subcellular location: Nucleus
By similarity. Cytoplasm
By similarity. Note: Predominantly nuclear
By similarity. HAMAP-Rule MF_03172
Domain: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis
By similarity. HAMAP-Rule MF_03172
Sequence similarities: Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.
Sequence caution: The sequence AAH45275.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH54975.2 differs from that shown. Reason: Erroneous initiation.
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Product Notes
The cmpk1 cmpk1 (Catalog #AAA644249) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CMPK1 (UMP-CMP Kinase, Deoxycytidylate Kinase, CK, dCMP Kinase, Uridine Monophosphate/Cytidine Monophosphate Kinase, UMP/CMP Kinase, UMP/CMPK, CMK, CMPK, UCK, UMK, UMPK) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CMPK1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the cmpk1 cmpk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MLSRCRSRLL HVLGLSFLLQ TRRPILLCSP RLMKPLVVFV LGGPGAGKGT QCARIVEKYG YTHLSAGELL RDERKNPDSQ YGELIEKYIK EGKIVPVEIT ISLLKREMDQ TMAANAQKNK FLIDGFPRNQ DNLQGWNKTM DGKADVSFVL FFDCNNEICI ERCLERGKSS GRSDDNRESL EKRIQTYLQS TKPIIDLYEE MGKVKKIDAS KSVDEVFDEV VQIFDKEG. It is sometimes possible for the material contained within the vial of "CMPK1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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