Rabbit anti-Human CLEC4M Polyclonal Antibody | anti-CLEC4M antibody
CLEC4M Antibody
Reactivity
Human
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
CLEC4M; Polyclonal Antibody; CLEC4M Antibody; C type lectin domain family 4; member M; C-type lectin domain family 4 member M; CD209 antigen like; CD209 antigen like protein 1; CD209 antigen-like protein 1; CD209L; CD209L1; CD299; CD299 antigen; CLC4M_HUMAN; DC SIGN related protein; DC SIGN2; DC SIGNR; DC-SIGN-related protein; DC-SIGN2; DC-SIGNR; DCSIGN related protein; DCSIGNR; Dendritic cell-specific ICAM-3-grabbing non-integrin 2; HP10347; L SIGN; L-SIGN; Liver/lymph node specific ICAM3 grabbing nonintegrin; Liver/lymph node-specific ICAM-3-grabbing non-integrin; LSIGN; Mannose binding C type lectin DC SIGNR; MGC129964; MGC47866; anti-CLEC4M antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
CLEC4M Antibody detects endogenous levels of CLEC4M.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-CLEC4M antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human CLEC4M.
Conjugation
Unconjugated
Similarity
The tandem repeat domain, also called neck domain, mediates oligomerization.
Subunit Structure
Homotetramer.(Microbial infection) Interacts with ebola virus glycoprotein.(Microbial infection) Interacts with hepatitis C virus E1 and E2 protein.(Microbial infection) Interacts with HIV-1 gp120.(Microbial infection) Interacts with human coronavirus 229E spike glycoprotein.(Microbial infection) Interacts with human cytomegalovirus/HHV-5 gB protein.(Microbial infection) Interacts with influenzavirus hemagglutinin.(Microbial infection) Interacts with SARS coronavirus spike glycoprotein.(Microbial infection) Interacts with west-nile virus envelope protein E.(Microbial infection) Interacts with Japanese encephalitis virus E protein.(Microbial infection) Interacts with Marburg virus glycoprotein.(Microbial infection) Interacts with M.bovis LprG.
Tissue Specificity
Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells.
Function
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.(Microbial infection) Acts as an attachment receptor for Ebolavirus.(Microbial infection) Acts as an attachment receptor for Hepatitis C virus.(Microbial infection) Acts as an attachment receptor for HIV-1.(Microbial infection) Acts as an attachment receptor for Human coronavirus 229E.(Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5.(Microbial infection) Acts as an attachment receptor for Influenzavirus.(Microbial infection) Acts as an attachment receptor for SARS coronavirus.(Microbial infection) Acts as an attachment receptor for West-nile virus.(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.(Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein.(Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-CLEC4M antibody
NCBI and Uniprot Product Information
NCBI GeneID
UniProt Accession #
Molecular Weight
Predicted Mol.Wt.: 45kDa(Calculated)
UniProt Protein Name
C-type lectin domain family 4 member M
Protein Family
UniProt Gene Name
CLEC4M
UniProt Synonym Gene Names
CD209L; CD209L1; CD299; DC-SIGNR; DC-SIGN2; L-SIGN
UniProt Entry Name
CLC4M_HUMAN
Uniprot Description
CLEC4M: Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. Is presumably a coreceptor for the SARS coronavirus. 10 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19p13
Cellular Component: integral to plasma membrane; membrane
Molecular Function: calcium-dependent protein binding; viral receptor activity; virion binding
Biological Process: cell-cell recognition; regulation of blood coagulation; regulation of gene expression; virion attachment to host cell surface receptor; virus-host interaction
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Product Notes
The CLEC4M clec4m (Catalog #AAA9630800) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CLEC4M Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CLEC4M can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the CLEC4M clec4m for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CLEC4M, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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