Rabbit CLDN7 Polyclonal Antibody | anti-CLDN7 antibody

CLDN7 Polyclonal Antibody

Cat. Num. AAA2525097

• Gene Names: CLDN7; CLDN-7; CEPTRL2; CPETRL2; Hs.84359; claudin-1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: CLDN7; Polyclonal Antibody; CLDN7 Polyclonal Antibody; CLDN-7; CEPTRL2; CPETRL2; Hs.84359; claudin-1; anti-CLDN7 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.1mg/mL (varies by lot)
• Sequence Length: 211

• Applicable Applications for anti-CLDN7 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:1000-1:3000; IHC: 1:50-1:150
• Immunogen: Synthetic peptide of human CLDN7
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of Human liver cancer tissue using CLDN7 Polyclonal Antibody at dilution of 1:1050)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colon cancer using CLDN7 Polyclonal Antibody at dilution of 1:50)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human stomach cancer using CLDN7 Polyclonal Antibody at dilution of 1:50)

Related Product Information for anti-CLDN7 antibody

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc. . Alternatively spliced transcript variants encoding different isoforms have been found.

NCBI and Uniprot Product Information

• NCBI GI #: 311033475
• NCBI GeneID: 1366
• Molecular Weight: 16,837 Da
• NCBI Official Full Name: Claudin-7
• NCBI Official Synonym Full Names: claudin 7
• NCBI Official Symbol: CLDN7
• NCBI Official Synonym Symbols: CLDN-7; CEPTRL2; CPETRL2; Hs.84359; claudin-1
• NCBI Protein Information: claudin-7; clostridium perfringens enterotoxin receptor-like 2
• UniProt Protein Name: Claudin-7
• Protein Family: Claudin
• UniProt Gene Name: CLDN7
• UniProt Synonym Gene Names: CEPTRL2; CPETRL2; CLDN-7
• UniProt Entry Name: CLD7_HUMAN

NCBI Description

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010]

Uniprot Description

Claudin-7: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Cell adhesion

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: tight junction; basolateral plasma membrane; integral to membrane; lateral plasma membrane

Molecular Function: identical protein binding; protein binding; structural molecule activity

Biological Process: calcium-independent cell-cell adhesion