Rabbit anti-Human, Mouse CLDN4 Polyclonal Antibody | anti-CLDN4 antibody

CLDN4, CT (CLDN4, CPER, CPETR1, WBSCR8, Claudin-4, Clostridium perfringens enterotoxin receptor, Williams-Beuren syndrome chromosomal region 8 protein) (FITC)

Cat. Num. AAA6286506

• Gene Names: CLDN4; CPER; CPE-R; CPETR; CPETR1; WBSCR8; hCPE-R
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CLDN4; Polyclonal Antibody; CT (CLDN4; CPER; CPETR1; WBSCR8; Claudin-4; Clostridium perfringens enterotoxin receptor; Williams-Beuren syndrome chromosomal region 8 protein) (FITC); Williams-Beuren syndrome chromosomal region 8 protein; anti-CLDN4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human CLDN4. Species crossreactivity: mouse
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-CLDN4 antibody: Western Blot (WB), FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 171-197 in the C-terminal region of human CLDN4, UniProt Accession #O14493.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of mouse heart tissue lysates (35ug/lane) usingMBS644560. CLDN4 (arrow) was detected using the purified Pab.)

Related Product Information for anti-CLDN4 antibody

CLDN4 is an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre-and postnatal life.

Product Categories/Family for anti-CLDN4 antibody

Antibodies; Claudin

References

Papageorgis, P., et al. Cancer Res. 70(3):968-978(2010). Kimura, J., et al. J. Biol. Chem. 285(1):401-408(2010). Robertson, S.L., et al. Infect. Immun. 78(1):505-517(2010). Seckin, Y., et al. Acta Gastroenterol. Belg. 72(4):407-412(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 4502877
• NCBI GeneID: 1364
• NCBI Accession #: NP_001296.1
• NCBI GenBank Nucleotide #: NM_001305.3
• UniProt Accession #: O14493
• Molecular Weight: 22,077 Da
• NCBI Official Full Name: claudin-4
• NCBI Official Synonym Full Names: claudin 4
• NCBI Official Symbol: CLDN4
• NCBI Official Synonym Symbols: CPER; CPE-R; CPETR; CPETR1; WBSCR8; hCPE-R
• NCBI Protein Information: claudin-4; CPE-receptor; Clostridium perfringens enterotoxin receptor 1; Williams-Beuren syndrome chromosomal region 8 protein
• UniProt Protein Name: Claudin-4
• Protein Family: Claudin
• UniProt Gene Name: CLDN4
• UniProt Synonym Gene Names: CPER; CPETR1; WBSCR8; CPE-R
• UniProt Entry Name: CLD4_HUMAN

NCBI Description

This gene encodes an integral membrane protein, which belongs to the claudin family. The protein is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. [provided by RefSeq, Jul 2008]

Uniprot Description

Claudin-4: Plays a major role in tight junction-specific obliteration of the intercellular space. CLDN4 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the claudin family.

Protein type: Membrane protein, multi-pass; Cytoskeletal; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: tight junction; apicolateral plasma membrane; integral to plasma membrane; apical plasma membrane; basal plasma membrane; plasma membrane; lateral plasma membrane

Molecular Function: identical protein binding; transmembrane receptor activity; structural molecule activity

Biological Process: female pregnancy; response to progesterone stimulus; signal transduction; calcium-independent cell-cell adhesion