Rabbit anti-Human, Mouse CLDN14 Polyclonal Antibody | anti-CLDN14 antibody

CLDN14 Rabbit pAb

Cat. Num. AAA4759508

• Gene Names: CLDN14; DFNB29
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Affinity purified
• Synonyms: CLDN14; Polyclonal Antibody; CLDN14 Rabbit pAb; claudin 14; DFNB29; anti-CLDN14 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: 0.2mg/ml (varies by lot)

• Applicable Applications for anti-CLDN14 antibody: Western Blot (WB)
• Application Notes: WB: 1:200-1:1000
• Immunogen: Synthetic peptide of human CLDN14
• Conjugation: Unconjugated
• Modification: Unmodified
• Preparation and Storage: Store at 4 degree C for short term. Store at -20 degree C for long term. Avoid freeze/thaw cycle.

Western Blot (WB)

(Western Blot analysis of CLDN14 in Mouse pancreas tissue using CLDN14 Rabbit pAb at dilution 1/200)

Related Product Information for anti-CLDN14 antibody

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 225703140
• NCBI GeneID: 23562
• NCBI Accession #: NP_001139550.1
• NCBI GenBank Nucleotide #: NM_001146078.2
• UniProt Accession #: O95500
• Molecular Weight: 25,699 Da
• NCBI Official Full Name: claudin-14
• NCBI Official Synonym Full Names: claudin 14
• NCBI Official Symbol: CLDN14
• NCBI Official Synonym Symbols: DFNB29
• NCBI Protein Information: claudin-14
• UniProt Protein Name: Claudin-14
• Protein Family: Claudin
• UniProt Gene Name: CLDN14
• UniProt Entry Name: CLD14_HUMAN

NCBI Description

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]

Uniprot Description

Claudin-14: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Defects in CLDN14 are the cause of deafness autosomal recessive type 29 (DFNB29). DFNB29 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the claudin family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: tight junction; endoplasmic reticulum; integral to membrane; plasma membrane

Molecular Function: identical protein binding; structural molecule activity

Biological Process: intercellular junction assembly and maintenance; protein complex assembly; calcium-independent cell-cell adhesion

Disease: Deafness, Autosomal Recessive 29