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Western Blot (WB) (Anti-CHML Antibodyat 1:1000 dilution + H.skeletal muscle tissue lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilutionPredicted band size : 74 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Rabbit CLCN4 Polyclonal Antibody | anti-CLCN4 antibody

CLCN4 Antibody

Gene Names
CLCN4; CLC4; ClC-4; ClC-4A
Reactivity
Human, mouse, rat
Applications
Western Blot, ELISA
Purity
Purified Rabbit Polyclonal Antibody (Pab)
Synonyms
CLCN4; Polyclonal Antibody; CLCN4 Antibody; H(+)/Cl(-) exchange transporter 4; Chloride channel protein 4; ClC-4; Chloride transporter ClC-4; anti-CLCN4 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, mouse, rat
Clonality
Polyclonal
Purity/Purification
Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
Concentration
1mg/ml (varies by lot)
Sequence Positions
201-260
Sequence Length
666
Applicable Applications for anti-CLCN4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB~~ 1:1000
Antigen Type
synthetic peptide
Antigen Source
KLH conjugated synthetic peptide derived from human CLCN4
Preparation and Storage
Store at -20 degree C.Stable for 12 months from date of receipt

Western Blot (WB)

(Anti-CHML Antibodyat 1:1000 dilution + H.skeletal muscle tissue lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilutionPredicted band size : 74 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Western Blot (WB) (Anti-CHML Antibodyat 1:1000 dilution + H.skeletal muscle tissue lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilutionPredicted band size : 74 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Related Product Information for anti-CLCN4 antibody
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons.
Product Categories/Family for anti-CLCN4 antibody
References
van Slegtenhorst M.A.,et al.Hum. Mol. Genet. 3:547-552(1994).
Kawasaki M.,et al.Am. J. Physiol. 277:C948-C954(1999).
Rae J.L.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
84917
NCBI Official Full Name
H(+)/Cl(-) exchange transporter 4 isoform 2
NCBI Official Synonym Full Names
chloride channel, voltage-sensitive 4
NCBI Official Symbol
CLCN4
NCBI Official Synonym Symbols
CLC4; ClC-4; ClC-4A
NCBI Protein Information
H(+)/Cl(-) exchange transporter 4
UniProt Protein Name
H(+)/Cl(-) exchange transporter 4
UniProt Gene Name
CLCN4
UniProt Synonym Gene Names
ClC-4
UniProt Entry Name
CLCN4_HUMAN

NCBI Description

The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]

Uniprot Description

CLCN4: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Belongs to the chloride channel (TC 2.A.49) family. ClC-4/CLCN4 subfamily.

Protein type: Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral; Transporter

Chromosomal Location of Human Ortholog: Xp22.3

Cellular Component: early endosome membrane; late endosome membrane; integral to membrane; endosome membrane

Molecular Function: chloride channel activity; voltage-gated chloride channel activity; ATP binding; antiporter activity

Biological Process: transport; chloride transport; transmembrane transport

Research Articles on CLCN4

Similar Products

Product Notes

The CLCN4 clcn4 (Catalog #AAA9213238) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 201-260. The CLCN4 Antibody reacts with Human, mouse, rat and may cross-react with other species as described in the data sheet. AAA Biotech's CLCN4 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~ 1:1000. Researchers should empirically determine the suitability of the CLCN4 clcn4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CLCN4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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