Rabbit anti-Human CLCA4 Polyclonal Antibody | anti-CLCA4 antibody
CLCA4 Antibody
Gene Names
CLCA4; CaCC; CaCC2
Reactivity
Human
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
CLCA4; Polyclonal Antibody; CLCA4 Antibody; 30 kDa form; CaCC-2; Calcium-activated chloride channel family member 4; Calcium-activated chloride channel protein 2; Calcium-activated chloride channel regulator 4; Clca4; CLCA4_HUMAN; hCaCC-2; hCLCA4; anti-CLCA4 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
CLCA4 Antibody detects endogenous levels of CLCA4.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-CLCA4 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human CLCA4.
Conjugation
Unconjugated
Similarity
The metalloprotease region is responsible for autoproteolytic processing. It can also cross-cleave other CLCA substrates. Belongs to the CLCR family.
Post Translational Modifications
The translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a N-terminal and a C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.
Tissue Specificity
Primarily expressed in the digestive tract, mainly in colon. Detected in smaller amounts in brain, urogenital organs, testis, and salivary and mammary glands. Highly expressed in the epithelial layer and submucosal gland of the inferior turbinate mucosa. Lower levels in the epithelial layer of nasal polyp.
Function
May be involved in mediating calcium-activated chloride conductance.
Note
The C-terminus 30 kDa form is anchored to the membrane. The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Product Categories/Family for anti-CLCA4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
919
NCBI Official Full Name
Calcium-activated chloride channel regulator 4
NCBI Official Synonym Full Names
chloride channel accessory 4
NCBI Official Symbol
CLCA4
NCBI Official Synonym Symbols
CaCC; CaCC2
NCBI Protein Information
calcium-activated chloride channel regulator 4; caCC-2; hCLCA4; hCaCC-2; calcium-activated chloride channel protein 2; calcium-activated chloride channel family member 4; chloride channel, calcium activated, family member 4
UniProt Protein Name
Calcium-activated chloride channel regulator 4
Protein Family
UniProt Gene Name
CLCA4
UniProt Synonym Gene Names
CaCC2; hCLCA4; CaCC-2; hCaCC-2
UniProt Entry Name
CLCA4_HUMAN
NCBI Description
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008]
Uniprot Description
CLCA4: May be involved in mediating calcium-activated chloride conductance. Belongs to the CLCR family.
Protein type: Channel, chloride; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p22.3
Cellular Component: integral to plasma membrane; apical plasma membrane; plasma membrane
Molecular Function: chloride channel activity; metallopeptidase activity; metal ion binding
Biological Process: transport; chloride transport; proteolysis; transmembrane transport
