Rabbit anti-Mouse Claudin 1 Polyclonal Antibody | anti-CLDN1 antibody

Claudin 1 Polyclonal Antibody

Cat. Num. AAA2556036

• Gene Names: Cldn1; AI596271
• Reactivity: Mouse
• Applications: Immunohistochemistry
• Purity: Affinity purification
• Synonyms: Claudin 1; Polyclonal Antibody; Claudin 1 Polyclonal Antibody; Claudin-1; Claudin1; CLD 1; CLD1; CLDN 1; ILVASC; SEMP 1; SEMP1; Senescence associated epithelial membrane protein 1; Senescence associated epithelial membrane protein; Senescence-associated epithelial membrane protein; anti-CLDN1 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purification
• Form/Format: PBS with 0.02% sodium azide, 100 ug/ml BSA and 50% glycerol.
• Sequence Length: 211

• Applicable Applications for anti-CLDN1 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:200-1:500
• Immunogen: KLH conjugated synthetic peptide corresponding to Mouse claudin-1
• Conjugation: Unconjugated
• Note: Centrifuge before opening to ensure complete recovery of vial contents.
• Preparation and Storage: Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded Mouse lung using Claudin 1 Polyclonal Antibody at dilution of 1:200.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded Mouse colon using Claudin 1 Polyclonal Antibody at dilution of 1:200.)

Immunohistochemistry (IHC)

(Immunohistochemistry analysis of paraffin-embedded Mouse liver using Claudin 1 Polyclonal Antibody at dilution of 1:200.)

Related Product Information for anti-CLDN1 antibody

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

Product Categories/Family for anti-CLDN1 antibody

Cancer; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 7710002
• NCBI GeneID: 12737
• NCBI Accession #: NP_057883.1
• NCBI GenBank Nucleotide #: NM_016674.4
• UniProt Accession #: O88551
• NCBI Official Full Name: claudin-1
• NCBI Official Synonym Full Names: claudin 1
• NCBI Official Symbol: Cldn1
• NCBI Official Synonym Symbols: AI596271
• NCBI Protein Information: claudin-1
• UniProt Protein Name: Claudin-1
• Protein Family: Claudin
• UniProt Gene Name: Cldn1

NCBI Description

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene die soon after birth as a consequence of dehydration from trandermal water loss, indicating that this gene is indispensable for creating and maintaining the epidermal barrier. The protein encoded by this gene also has gastric tumor suppressive activity, and is a key factor for hepatitis C virus (HCV) entry. [provided by RefSeq, Aug 2010]

Uniprot Description

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.