Rabbit CIAPIN1 Polyclonal Antibody | anti-CIAPIN1 antibody

CIAPIN1 Antibody

Cat. Num. AAA9629215

• Gene Names: CIAPIN1; DRE2; PRO0915; Anamorsin; 2810413N20Rik
• Reactivity: Human, Mouse, Rat
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: CIAPIN1; Polyclonal Antibody; CIAPIN1 Antibody; 2810413N20Rik; Anamorsin; CIAPIN 1; CPIN1_HUMAN; Cytokine induced apoptosis inhibitor 1; Cytokine-induced apoptosis inhibitor 1; DRE2; Fe-S cluster assembly protein DRE2 homolog; Predicted protein of HQ0915; PRO0915; anti-CIAPIN1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: CIAPIN1 Antibody detects endogenous levels of total CIAPIN1.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-CIAPIN1 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from Human MYOCD.
• Conjugation: Unconjugated
• Similarity: The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation. The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters. Belongs to the anamorsin family.
• Subunit Structure: Monomer. Interacts with NDOR1; its oxidized form can be reduced by NDOR1. Interacts with CHCHD4 and may be a substrate for CHCHD4 chaperone activity.
• Tissue Specificity: Ubiquitously expressed. Highly expressed in heart, liver and pancreas.
• Function: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity).
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-CIAPIN1 antibody

Cytoplasm; Nucleus; Mitochondrion intermembrane space; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 89274169
• NCBI GeneID: 57019
• NCBI Accession #: NP_064709.2
• NCBI GenBank Nucleotide #: NM_020313.2
• UniProt Accession #: Q6FI81; O75206; O75207; Q9H0W1; Q9P1L7; A8K8B6
• Molecular Weight: 32,213 Da
• NCBI Official Full Name: anamorsin
• NCBI Official Synonym Full Names: cytokine induced apoptosis inhibitor 1
• NCBI Official Symbol: CIAPIN1
• NCBI Official Synonym Symbols: DRE2; PRO0915; Anamorsin; 2810413N20Rik
• NCBI Protein Information: anamorsin; CIAPIN1; cytokine-induced apoptosis inhibitor 1; fe-S cluster assembly protein DRE2 homolog; predicted protein of HQ0915
• UniProt Protein Name: Anamorsin
• Protein Family: Anamorsin
• UniProt Gene Name: CIAPIN1
• UniProt Entry Name: CPIN1_HUMAN

NCBI Description

CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]

Uniprot Description

CIAPIN1: May be required for the maturation of extramitochondrial Fe/S proteins. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells. Belongs to the anamorsin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis

Chromosomal Location of Human Ortholog: 16q21

Cellular Component: nucleoplasm; cytoplasm; nucleolus; mitochondrial intermembrane space

Molecular Function: 2 iron, 2 sulfur cluster binding; protein binding; electron carrier activity; metal ion binding

Biological Process: apoptosis; iron-sulfur cluster assembly; hemopoiesis; negative regulation of apoptosis