Rabbit anti-Human CHRFAM7A Polyclonal Antibody | anti-CHRFAM7A antibody

CHRFAM7A Antibody (C-Term)

Cat. Num. AAA9216081

• Gene Names: CHRFAM7A; D-10; CHRNA7; CHRNA7-DR1
• Reactivity: Human
• Applications: Western Blot
• Synonyms: CHRFAM7A; Polyclonal Antibody; CHRFAM7A Antibody (C-Term); Purified Rabbit Polyclonal Antibody (Pab); CHRNA7-FAM7A fusion protein; CHRNA7-DR1; D-10; anti-CHRFAM7A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Ig
• Specificity: This CHRFAM7A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 317-349 amino acids from human CHRFAM7A.
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Length: 412

• Applicable Applications for anti-CHRFAM7A antibody: Western Blot (WB)
• Application Notes: WB ~~ 1:2000
• Antigen Source: Human
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Anti-CHRFAM7A Antibody (C-Term) at 1:2000 dilution + U-87 MG whole cell lysateLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.Predicted band size : 46 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Product Categories/Family for anti-CHRFAM7A antibody

Neuroscience

References

Ota T.,et al.Nat. Genet. 36:40-45(2004). Zody M.C.,et al.Nature 440:671-675(2006). Gault J.,et al.Genomics 52:173-185(1998).

NCBI and Uniprot Product Information

• NCBI GI #: 23312388
• NCBI GeneID: 89832
• NCBI Accession #: NP_647536.1
• NCBI GenBank Nucleotide #: NM_139320.1
• UniProt Accession #: Q494W8; A8KAB9
• Molecular Weight: 46218
• NCBI Official Full Name: CHRNA7-FAM7A fusion protein isoform 1
• NCBI Official Synonym Full Names: CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion
• NCBI Official Symbol: CHRFAM7A
• NCBI Official Synonym Symbols: D-10; CHRNA7; CHRNA7-DR1
• NCBI Protein Information: CHRNA7-FAM7A fusion protein
• UniProt Protein Name: CHRNA7-FAM7A fusion protein
• Protein Family: CHRNA7-FAM7A fusion protein
• UniProt Gene Name: CHRFAM7A
• UniProt Entry Name: CRFM7_HUMAN

NCBI Description

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008]

Uniprot Description

CHRFAM7A: Belongs to the ligand-gated ion channel (TC 1.A.9) family

Protein type: Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q13.1

Cellular Component: nicotinic acetylcholine-gated receptor-channel complex; neuron projection; postsynaptic density; dendritic spine; lipid raft; presynaptic membrane; asymmetric synapse; growth cone; cell soma; axon; apical plasma membrane; cytoplasm; synapse; dendritic shaft; external side of plasma membrane

Molecular Function: acetylcholine receptor activity; drug binding; nicotinic acetylcholine-activated cation-selective channel activity; acetylcholine binding; protein kinase binding; ATPase binding; adenylate cyclase binding

Biological Process: response to food; B cell activation; T cell activation; generation of action potential; behavioral response to nicotine; endocytosis; dopamine biosynthetic process; negative regulation of interleukin-1 beta production; behavioral response to ethanol; signal transduction; regulation of norepinephrine secretion; positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressure; memory; neurological system process; synaptic transmission, cholinergic; generation of ovulation cycle rhythm; regulation of membrane potential; sperm motility; regulation of synaptic transmission, dopaminergic; negative regulation of inflammatory response; calcium ion transport; negative regulation of interleukin-6 production; associative learning