Rabbit CHP2 Polyclonal Antibody | anti-CHP2 antibody

Anti-CHP2 Antibody (Internal)

Cat. Num. AAA2401457

• Reactivity: Human; Predicted: Mouse, Rat, Monkey
• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: CHP2; Polyclonal Antibody; Anti-CHP2 Antibody (Internal); Rabbit Polyclonal (IgG) to Human CHP2; HCA520; anti-CHP2 antibody

• Host: Rabbit
• Reactivity: Human; Predicted: Mouse, Rat, Monkey
• Clonality: Polyclonal
• Specificity: Recognizes endogenous levels of CHP2 protein.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, pH 7.3, 0.01% sodium azide, 30% glycerol.
• Sequence Length: 196

• Applicable Applications for anti-CHP2 antibody: Immunohistochemistry (IHC) Paraffin, Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: IHC-P: 1:100; IP: 1:10-1:100; WB: 1:500-1:1000
• Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the central region of human CHP2.
• Conjugation: Unconjugated
• Epitope: Internal
• Preparation and Storage: Store at -20 degree C.; Aliquot to avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE))

Western Blot (WB)

(Western blot analysis of CHP2 expression in K562 (A); HT29 (B) whole cell lysates.)

Related Product Information for anti-CHP2 antibody

Functions as an integral cofactor in cell pH regulation by controllingplasma membrane-type Na+/H+ exchange activity. Binds to and activatesSLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasingthe phosphatase activity of PPP3CA in a calcium-dependent manner.Activator of the calcineurin/NFAT signaling pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 11545811
• NCBI GeneID: 63928
• NCBI Accession #: NP_071380.1
• NCBI GenBank Nucleotide #: NM_022097.3
• UniProt Accession #: O43745; A8K2I8
• Molecular Weight: 22,452 Da
• NCBI Official Full Name: calcineurin B homologous protein 2
• NCBI Official Synonym Full Names: calcineurin like EF-hand protein 2
• NCBI Official Symbol: CHP2
• NCBI Protein Information: calcineurin B homologous protein 2
• UniProt Protein Name: Calcineurin B homologous protein 2
• Protein Family: Calcineurin B homologous protein
• UniProt Gene Name: CHP2
• UniProt Synonym Gene Names: HCA520

NCBI Description

This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homologous protein 1, is located on Chromosome 15 and is an inhibitor of calcineurin activity and has a genetic phenotype associated with Parkinson's Disease (OMIM:606988). This gene was initially identified as a tumor-associated antigen and was previously referred to as Hepatocellular carcinoma-associated antigen 520. [provided by RefSeq, Jul 2013]

Uniprot Description

Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.